philhwang.bsky.social
@philhwang.bsky.social
PhD Student in Anne Schaefer's Lab at Mount Sinai | Regulation of microglia and neuronal states | NIA F31 Fellow
Reposted
Protective Microglia Subtype Offers Potential New Therapeutic Pathway in Alzheimer’s Disease 🧠🛡️

A new nature.com study by the Schaefer lab and reseachers at Mount Sinai Medical Center, with rockefeller.edu and cuny.edu, identifies a protective state of microglia.

www.nature.com/articles/s41...
Lymphoid gene expression supports neuroprotective microglia function - Nature
PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunother...
www.nature.com
November 5, 2025 at 4:32 PM
Reposted
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
September 11, 2025 at 5:07 PM