and the collaboration with the @broadinstitute.org of MIT and Harvard, Patrick Ellinor and the team of Dr. Paul Ridker!

@mgbresearch.bsky.social @harvardmed.bsky.social
@herzmedizin.bsky.social @dgk-org.bsky.social @herzmedizin.bsky.social

My sincere thanks for the incredible support and the fantastic collaboration goes to my mentors for this work at the TIMI Study Group: Nicholas Marston, Christian Ruff, David Berg, Giorgio Melloni, Bob Giugliano, Dave Morrow, Eugene Braunwald and Marc Sabatine

❗These findings highlight the potential of having polygenic information available and how it could complement traditional risk assessment, offering the opportunity to move us closer to a personalised prevention of HF.

➡️ Importantly, adding the HF PRS to clinical models improved prediction of new-onset HF and provided value across both elevated and low cardiovascular risk populations.

In a pooled analysis of nearly 75,000 individuals, we found that a heart failure PRS was a powerful and independent predictor of new-onset HF—with high genetic risk linked to a five-fold increase in events in patients at elevated cardiovascular risk.

I'm very excited to share our new paper in @jaccjournals.bsky.social on the role of polygenic risk scores (PRS) in predicting heart failure development.