Rapamycin is a fascinating molecule. I worked on it in the late eighties (89-91). Suren Sehgal was a friend of mine. We had a Costco Mayonnaise sized jar of the stuff that we were trying to make analogs of. A few patents and papers came out of it and then I left for greener pastures.
October 21, 2025 at 4:00 PM
Rapamycin is a fascinating molecule. I worked on it in the late eighties (89-91). Suren Sehgal was a friend of mine. We had a Costco Mayonnaise sized jar of the stuff that we were trying to make analogs of. A few patents and papers came out of it and then I left for greener pastures.
This is going back about 40 years ago so I may be remembering it wrong, but seems like I displaced an aryl bromide with benzyl mercaptan using DBU in benzene and then removed the benzyl with a sodium in ammonia reduction to give the aryl mercaptan. So that's a different sulfur delivery agent.
June 11, 2025 at 4:19 PM
This is going back about 40 years ago so I may be remembering it wrong, but seems like I displaced an aryl bromide with benzyl mercaptan using DBU in benzene and then removed the benzyl with a sodium in ammonia reduction to give the aryl mercaptan. So that's a different sulfur delivery agent.
Wow! I wonder if there are some people who know ahead of time what he's going to do? Just curious.
May 27, 2025 at 3:16 PM
Wow! I wonder if there are some people who know ahead of time what he's going to do? Just curious.
The ACS is a publishing company masquerading as a professional society. It has no soul to be brave with.
May 10, 2025 at 8:54 PM
The ACS is a publishing company masquerading as a professional society. It has no soul to be brave with.
ACS is a publishing company masquerading as a professional society.
After 45 years, I've found that looking at it that way and you're less likely to be disappointed.
After 45 years, I've found that looking at it that way and you're less likely to be disappointed.
April 25, 2025 at 1:10 PM
ACS is a publishing company masquerading as a professional society.
After 45 years, I've found that looking at it that way and you're less likely to be disappointed.
After 45 years, I've found that looking at it that way and you're less likely to be disappointed.
Trump's approval rating is still way too high. Who are these morons anyway? Never mind, I went to high school with them.
April 22, 2025 at 1:23 AM
Trump's approval rating is still way too high. Who are these morons anyway? Never mind, I went to high school with them.
"Inaccuracies and failures" is a little rough, don't you think? We know proteins are dynamic and can be induced to form alternative states when presented with environments not sampled in the PDB. The failure is on the researcher who thinks Alphafold or the PDB presents the whole story.
April 7, 2025 at 2:07 PM
"Inaccuracies and failures" is a little rough, don't you think? We know proteins are dynamic and can be induced to form alternative states when presented with environments not sampled in the PDB. The failure is on the researcher who thinks Alphafold or the PDB presents the whole story.
My understanding is that Apple did not make a contribution to Trump's inauguration. The $1M came from Tim Cook. Not sure how the others were financed.
January 14, 2025 at 1:36 PM
My understanding is that Apple did not make a contribution to Trump's inauguration. The $1M came from Tim Cook. Not sure how the others were financed.
I tend to agree. It was an uninspired decision.
December 12, 2024 at 12:51 PM
I tend to agree. It was an uninspired decision.