Lynn Petukhova
@petukhova.bsky.social
Our group reviews GWAS of hair traits, generating a single resource of genes that exert clinically relevant effects on human HFs. This knowledge will help to translate mechanistic knowledge about hair follicles that has been generated from animal models.
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
August 22, 2025 at 4:07 PM
Our group reviews GWAS of hair traits, generating a single resource of genes that exert clinically relevant effects on human HFs. This knowledge will help to translate mechanistic knowledge about hair follicles that has been generated from animal models.
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
Reposted by Lynn Petukhova
New research from the Zamponi Lab! They've identified a novel USP5 mutation linked to pain insensitivity. Their study, using a CRISPR knock-in mouse model, reveals R24W USP5 as a dominant-negative regulator of Cav3.2 channels, leading to reduced pain. rupress.org/jem/article/...
A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain | Journal of Experimental Medicine | Rockefeller University Press
The manuscript reports on patient with a USP5 mutation that gives rise to insensitivity to pain. The patient’s pathology is phenocopied in a knock-in mouse
rupress.org
May 30, 2025 at 2:39 PM
New research from the Zamponi Lab! They've identified a novel USP5 mutation linked to pain insensitivity. Their study, using a CRISPR knock-in mouse model, reveals R24W USP5 as a dominant-negative regulator of Cav3.2 channels, leading to reduced pain. rupress.org/jem/article/...