We are looking for a postdoctoral fellow to join the lab to study how cortical microcircuits are organised at the single cell level using high throughput molecular methods. Please share and get in touch if interested!

www.crick.ac.uk/careers-stud...

\5 Long-range inputs onto single V1 neurons reveal the topography of feedback projections from higher visual areas, which mirrors the retinotopic organisation of the visual cortex.

4/ We apply BRISC in the mouse primary visual cortex, mapping 7,814 putative synaptic connections of 385 starter neurons and identifying layer- and cell-type-specific connectivity rules.

3/ Barcodes are read out from intact tissue sections using in situ sequencing, thus reconstructing presynaptic ensembles of individual starter neurons while preserving spatial information.

2/ BRISC uses random molecular barcodes transsynaptically transmitted by rabies viruses to map inputs of many neurons simultaneously, while maintaining single cell resolution. Connections between individual neurons are then identified by matching their barcode sequences.

📢 If you are at #SfN2023, check out the lab's posters from Yiran He (Sun AM) and Alex Becalick (Mon PM)! I'll be around as well, so send me a message if you'd like to meet and catch up! #SfN23

🚀 Don't miss your chance join @thecrick.bsky.social PhD programme, including projects in my lab! Interested in how neuronal activity, connectivity and gene expression all relate to each other in vivo?

Learn more and apply at crick.ac.uk/careers-stud...

🗓️ Deadline Nov 9! Please repost!