Mario R Mestre
@pentamorfico.bsky.social
Pro-prokaryote and phage phan, PhDoing at University of Copenhagen @microUCPH. MGEs, CRISPR, defense systems. RT=Reverse Transcriptase
Reposted by Mario R Mestre
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
October 17, 2025 at 5:22 PM
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Reposted by Mario R Mestre
The abstract submission & registration for #RdRpSummit2025 is NOW OPEN!!! 🎉🙌
Do you work on RNA virus discovery using RdRps? Are you joining the #ViBioM2025 in Portugal?
Consider submitting your research in one of our sessions!
More info: RdRp.io
Do you work on RNA virus discovery using RdRps? Are you joining the #ViBioM2025 in Portugal?
Consider submitting your research in one of our sessions!
More info: RdRp.io
February 19, 2025 at 9:10 PM
The abstract submission & registration for #RdRpSummit2025 is NOW OPEN!!! 🎉🙌
Do you work on RNA virus discovery using RdRps? Are you joining the #ViBioM2025 in Portugal?
Consider submitting your research in one of our sessions!
More info: RdRp.io
Do you work on RNA virus discovery using RdRps? Are you joining the #ViBioM2025 in Portugal?
Consider submitting your research in one of our sessions!
More info: RdRp.io
Reposted by Mario R Mestre
We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: www.biorxiv.org/content/10.1...
January 30, 2025 at 10:08 PM
We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: www.biorxiv.org/content/10.1...
Reposted by Mario R Mestre
For example, Crick speculated that DNA → protein might be possible but seemed unlikely.
He also suggested that RNA → DNA could be feasible, even though there was no evidence for it yet. This turned out to be prophetic.
He also suggested that RNA → DNA could be feasible, even though there was no evidence for it yet. This turned out to be prophetic.
January 29, 2025 at 11:16 PM
For example, Crick speculated that DNA → protein might be possible but seemed unlikely.
He also suggested that RNA → DNA could be feasible, even though there was no evidence for it yet. This turned out to be prophetic.
He also suggested that RNA → DNA could be feasible, even though there was no evidence for it yet. This turned out to be prophetic.
Reposted by Mario R Mestre
Most people misunderstand the Central Dogma.
In school, perhaps you were taught it as “DNA → RNA → protein.” But that’s a massive oversimplification.
Francis Crick’s real "Central Dogma" was about what *cannot* happen in a cell. Let’s break it down. 🧵
In school, perhaps you were taught it as “DNA → RNA → protein.” But that’s a massive oversimplification.
Francis Crick’s real "Central Dogma" was about what *cannot* happen in a cell. Let’s break it down. 🧵
January 29, 2025 at 11:16 PM
Most people misunderstand the Central Dogma.
In school, perhaps you were taught it as “DNA → RNA → protein.” But that’s a massive oversimplification.
Francis Crick’s real "Central Dogma" was about what *cannot* happen in a cell. Let’s break it down. 🧵
In school, perhaps you were taught it as “DNA → RNA → protein.” But that’s a massive oversimplification.
Francis Crick’s real "Central Dogma" was about what *cannot* happen in a cell. Let’s break it down. 🧵
Reposted by Mario R Mestre
Hello 🦋 #protein / #microbio / #BioML community! We are excited to release Gaia🌎, a context-aware protein search tool, extending protein search and discovery capabilities beyond sequence and structure, to include *genomic context*. Search your favorite protein sequences with on gaia.tatta.bio
November 19, 2024 at 3:07 PM
Hello 🦋 #protein / #microbio / #BioML community! We are excited to release Gaia🌎, a context-aware protein search tool, extending protein search and discovery capabilities beyond sequence and structure, to include *genomic context*. Search your favorite protein sequences with on gaia.tatta.bio