IPNA Pediatric Nephrology
@ped-neph.bsky.social
Original clinical research and reviews on all aspects of acute and chronic diseases affecting kidney function in children. Official journal of IPNA.
Pediatric solid organ transplantation recipients are at increased risk of diarrhea due to immunosuppression & epidemiological risk factors. Read this Research Letter re oral immunoglobulin for norovirus diarrhea in pediatric kidney transplant recipients.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 12, 2025 at 7:15 PM
Pediatric solid organ transplantation recipients are at increased risk of diarrhea due to immunosuppression & epidemiological risk factors. Read this Research Letter re oral immunoglobulin for norovirus diarrhea in pediatric kidney transplant recipients.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Nephrolithiasis (NL) & nephrocalcinosis (NC) are common pediatric kidney conditions globally. Read this Original Article on genetic causes of NL & NC in a pediatric population in Saudi Arabia. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 12, 2025 at 6:54 PM
Nephrolithiasis (NL) & nephrocalcinosis (NC) are common pediatric kidney conditions globally. Read this Original Article on genetic causes of NL & NC in a pediatric population in Saudi Arabia. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Rituximab is a therapeutic option in children w/refractory nephrotic syndrome (RNS), but the efficacy & safety of rituximab treatment remain unclear. Read this Systematic Review /Meta-analysis of rituximab efficacy in pediatric RNS. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 10, 2025 at 10:23 PM
Rituximab is a therapeutic option in children w/refractory nephrotic syndrome (RNS), but the efficacy & safety of rituximab treatment remain unclear. Read this Systematic Review /Meta-analysis of rituximab efficacy in pediatric RNS. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Hypernatremia is a challenging condition. A rapid increase in blood sodium can draw water out of brain cells. A rapid correction to a slow increase can cause cerebral swelling. Read this Editorial Commentary on thirst, sodium & the hospitalized child.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 7, 2025 at 7:26 PM
Hypernatremia is a challenging condition. A rapid increase in blood sodium can draw water out of brain cells. A rapid correction to a slow increase can cause cerebral swelling. Read this Editorial Commentary on thirst, sodium & the hospitalized child.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
CKD is in WHO’s noncommunicable diseases prevention program to reduce premature mortality by 33% by 2030. There are stark regional differences in CKD burden that disproportionally affects low-income countries. Read this Editorial Commentary on CKDu in children.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 6, 2025 at 6:19 PM
CKD is in WHO’s noncommunicable diseases prevention program to reduce premature mortality by 33% by 2030. There are stark regional differences in CKD burden that disproportionally affects low-income countries. Read this Editorial Commentary on CKDu in children.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Read this Editorial Commentary on improvisation, innovation, & inequity: peritoneal dialysis in low-resource settings.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 5, 2025 at 5:31 PM
Read this Editorial Commentary on improvisation, innovation, & inequity: peritoneal dialysis in low-resource settings.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
BK virus is a polyoma virus associated w/impaired graft function in kidney transplant recipients. After primary infection, the virus becomes latent in the renal/urinary epithelium. Read these Clinical Insights into BK virus nephropathy in a native kidney.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 4, 2025 at 5:20 PM
BK virus is a polyoma virus associated w/impaired graft function in kidney transplant recipients. After primary infection, the virus becomes latent in the renal/urinary epithelium. Read these Clinical Insights into BK virus nephropathy in a native kidney.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
GFR can be measured directly, or estimated from biomarkers like serum creatinine & cystatin C, or both. Measuring GFR in children is cumbersome. Read this Review of measuring & estimating GFR in children: state of the art in 2025. Free access this month.
bit.ly/47meymz
bit.ly/47meymz
November 3, 2025 at 8:37 PM
GFR can be measured directly, or estimated from biomarkers like serum creatinine & cystatin C, or both. Measuring GFR in children is cumbersome. Read this Review of measuring & estimating GFR in children: state of the art in 2025. Free access this month.
bit.ly/47meymz
bit.ly/47meymz
Albuminuria is a sensitive marker of early kidney injury & serves as a key indicator for the diagnosis of CKD. Read this Original Article on excessive screen time re albuminuria in adolescents: a finding from the China Nutrition and Health Surveillance.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 31, 2025 at 4:26 PM
Albuminuria is a sensitive marker of early kidney injury & serves as a key indicator for the diagnosis of CKD. Read this Original Article on excessive screen time re albuminuria in adolescents: a finding from the China Nutrition and Health Surveillance.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Read this Review of 2 of the more commonly used AI methods encountered in nephrology publications: machine vision based on convolutional neural networks (CNNs) & chatbots, such as ChatGPT, based on large language models. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 30, 2025 at 6:15 PM
Read this Review of 2 of the more commonly used AI methods encountered in nephrology publications: machine vision based on convolutional neural networks (CNNs) & chatbots, such as ChatGPT, based on large language models. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
AKI is an important complication in neonates w/hypoxic ischemic encephalopathy (HIE). Read this Original Article on the association between early lactate elimination trend & AKI in neonates w/HIE receiving therapeutic hypothermia.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 29, 2025 at 10:50 PM
AKI is an important complication in neonates w/hypoxic ischemic encephalopathy (HIE). Read this Original Article on the association between early lactate elimination trend & AKI in neonates w/HIE receiving therapeutic hypothermia.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Acute kidney disease (AKD) is kidney dysfunction lasting 7–90 days after AKI onset. Read this Original Article on neonatal AKD in the National Center for Child Health & Development (NCCHD)-neoAKI cohort in Japan. Topical Collection: Advances in Neonatal Nephrology.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 28, 2025 at 6:41 PM
Acute kidney disease (AKD) is kidney dysfunction lasting 7–90 days after AKI onset. Read this Original Article on neonatal AKD in the National Center for Child Health & Development (NCCHD)-neoAKI cohort in Japan. Topical Collection: Advances in Neonatal Nephrology.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Energy requirements of renal proximal tubular cells depend on mitochondrial fatty acid β-oxidation. Read these Clinical Insights on long-standing low-molecular-weight proteinuria: A proximal tubular mitochondrial enzyme impairment & EHHADH mutation.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 27, 2025 at 6:32 PM
Energy requirements of renal proximal tubular cells depend on mitochondrial fatty acid β-oxidation. Read these Clinical Insights on long-standing low-molecular-weight proteinuria: A proximal tubular mitochondrial enzyme impairment & EHHADH mutation.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
CKD of unknown etiology (CKDu) disproportionately affects young agricultural workers in Mesoamerica & South Asia who lack traditional risk factors for kidney disease. Read this Systematic Review/ Meta-analysis of outcomes in communities impacted by CKDu.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 24, 2025 at 8:08 PM
CKD of unknown etiology (CKDu) disproportionately affects young agricultural workers in Mesoamerica & South Asia who lack traditional risk factors for kidney disease. Read this Systematic Review/ Meta-analysis of outcomes in communities impacted by CKDu.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Advancements in pediatric cancer treatment have improved long-term survival. In childhood cancer survivors w/kidney failure, kidney transplant can be life-prolonging. Read this Educ Review of kidney disease & transplantation in childhood. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 24, 2025 at 7:46 PM
Advancements in pediatric cancer treatment have improved long-term survival. In childhood cancer survivors w/kidney failure, kidney transplant can be life-prolonging. Read this Educ Review of kidney disease & transplantation in childhood. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
With the advancement of large language models (LLMs), artificial intelligence has entered society & medicine. Read this Research Letter comparing German medical guidelines w/recommendations by LLMS using the example of hemolytic uremic syndrome.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 23, 2025 at 7:21 PM
With the advancement of large language models (LLMs), artificial intelligence has entered society & medicine. Read this Research Letter comparing German medical guidelines w/recommendations by LLMS using the example of hemolytic uremic syndrome.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Read Abstracts from the European Society for Paediatric Nephrology (ESPN) Congress in Athens, Greece, Oct. 13-18, 2025.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 23, 2025 at 6:25 PM
Read Abstracts from the European Society for Paediatric Nephrology (ESPN) Congress in Athens, Greece, Oct. 13-18, 2025.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Peritoneal dialysis (PD) sustains children w/CKD5 but promotes peritoneal membrane remodeling. Read this Original Article: Neutrophil extracellular traps drive peritoneal inflammation & tissue remodeling in pediatric PD. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 22, 2025 at 6:40 PM
Peritoneal dialysis (PD) sustains children w/CKD5 but promotes peritoneal membrane remodeling. Read this Original Article: Neutrophil extracellular traps drive peritoneal inflammation & tissue remodeling in pediatric PD. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Kidney replacement therapy (KRT) is used to treat critically ill children for many reasons, including hyperammonemia. KRT mgmt in children w/hyperammonemia not due to inborn errors of metabolism is challenging. Read this Management Dilemma for more. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 22, 2025 at 6:27 PM
Kidney replacement therapy (KRT) is used to treat critically ill children for many reasons, including hyperammonemia. KRT mgmt in children w/hyperammonemia not due to inborn errors of metabolism is challenging. Read this Management Dilemma for more. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Children on hemodialysis are vulnerable to musculoskeletal (MSK) abnormalities, which can lead to functional impairments & diminished health-related quality of life. Read this Original Article on MSK pain among children on hemodialysis. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 21, 2025 at 10:16 PM
Children on hemodialysis are vulnerable to musculoskeletal (MSK) abnormalities, which can lead to functional impairments & diminished health-related quality of life. Read this Original Article on MSK pain among children on hemodialysis. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Serum creatinine (SCr), a biomarker used to evaluate glomerular filtration rate (GFR), might be inaccurate in children w/sickle cell anemia (SCA). Read this Original Article on SCr- & cystatin C-based estimated GFR equations in African children w/SCA.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 21, 2025 at 10:04 PM
Serum creatinine (SCr), a biomarker used to evaluate glomerular filtration rate (GFR), might be inaccurate in children w/sickle cell anemia (SCA). Read this Original Article on SCr- & cystatin C-based estimated GFR equations in African children w/SCA.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Automated peritoneal dialysis consists of dwells w/the same dwell volume & time. Read this Original Article comparing double mini-peritoneal equilibration tests w/standard vs adapted dwell volumes & dwell times in children on chronic peritoneal dialysis.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 20, 2025 at 6:56 PM
Automated peritoneal dialysis consists of dwells w/the same dwell volume & time. Read this Original Article comparing double mini-peritoneal equilibration tests w/standard vs adapted dwell volumes & dwell times in children on chronic peritoneal dialysis.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Torsemide is preferred to furosemide in adults w/heart failure for its higher bioavailability & longer half-life. Read this Original Article on efficacy & safety of torsemide vs furosemide in pediatric patients w/nephrotic syndrome.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 20, 2025 at 6:02 PM
Torsemide is preferred to furosemide in adults w/heart failure for its higher bioavailability & longer half-life. Read this Original Article on efficacy & safety of torsemide vs furosemide in pediatric patients w/nephrotic syndrome.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Few randomized controlled trials are conducted in childhood nephrotic syndrome & global practice variation exists. Read this Original Article on childhood steroid sensitive nephrotic syndrome clinical trials: results from a Delphi consensus process.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 17, 2025 at 5:17 PM
Few randomized controlled trials are conducted in childhood nephrotic syndrome & global practice variation exists. Read this Original Article on childhood steroid sensitive nephrotic syndrome clinical trials: results from a Delphi consensus process.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
With limited donor availability & long wait times for deceased donor transplantation, ABO-incompatible kidney transplantation (ABOiKT) offers hope to children w/kidney failure. Read this Educ Review of the history & future landscape for pediatric ABOiKT.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
October 17, 2025 at 4:52 PM
With limited donor availability & long wait times for deceased donor transplantation, ABO-incompatible kidney transplantation (ABOiKT) offers hope to children w/kidney failure. Read this Educ Review of the history & future landscape for pediatric ABOiKT.
link.springer.com/article/10.1...
link.springer.com/article/10.1...