This resilience of healthy adult gut microbiomes to the intervention has implications for phage allotransplantation safety.
Big thanks to everyone involved, especially Dagmar and Jakub, PIs of the project. Working with you was a blast!

However, the convergence of recipient-to-donor phageomes confirmed that wild phages can integrate into recipient communities. The transplantation did not impact recipient gut bacteriomes.

The effects of phageome transplants on healthy adult gut microbiota was, however, still unknown. We show that experimental transplantation of phageomes from wild to captive mice did not cause major shifts in recipient phageomes.

First, comparison of wild and captive phageomes and bacteriomes revealed that wild mice phageomes exhibit higher alpha-diversity and interindividual variability. Previously it has been shown that disrupted bacteriomes in mouse models can be treated by transplanting healthy phageomes.