Paul Valdmanis
@paulvaldmanis.bsky.social
Associate Professor of Medical Genetics at the University of Washington studying ALS and Alzheimer's disease genetics and tandem repeats. Posts are my own.
Reposted by Paul Valdmanis
Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
The MUC19 gene: An evolutionary history of recurrent introgression and natural selection
We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...
www.science.org
August 21, 2025 at 7:36 PM
Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...
This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).
www.science.org/doi/10.1126/...