Candie Paulsen Lab
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paulsenlab.bsky.social
Candie Paulsen Lab
@paulsenlab.bsky.social
Candie Paulsen's biochemistry research group at Yale consisting of unique individuals unified in our use of diverse approaches to study pain signaling.
Reposted by Candie Paulsen Lab
In a new @natcomms.nature.com study, @yale.edu's @paulsenlab.bsky.social uncovers how the protein calmodulin regulates pain signaling! ⚡ This breakthrough could lead to better pain management strategies 💊

Read More 👇
news.yale.edu/2025/09/30/u...
Unraveling a painful mystery: Protein plays key role in modulating pain response
A new Yale study has uncovered the hidden mechanical move that may regulate pain signaling in the human body — and why it sometimes goes awry.
news.yale.edu
November 13, 2025 at 6:50 PM
🧠Pain sensors need to switch on fast—and off just as quickly.

In our new tour de force Nat Comms paper - led by the first Paulsen lab grad student - we show that calmodulin plays a key role in shutting down the TRPA1 pain receptor - a finding that could guide new pain therapies.

📰 rdcu.be/eJcMK
Calmodulin binding is required for calcium mediated TRPA1 desensitization
Nature Communications - For pain signaling to be useful, sensory receptors must rapidly detect noxious stimuli and efficiently turn off once the threat has passed. Here, the authors uncover a...
rdcu.be
October 2, 2025 at 6:46 PM
We had a great time at BPS 2025– learned a lot and made great connections. Congrats to Paulsen Lab grad student Isabel Romov for winning a Student Research Achievement Award! We celebrated at Disneyland. ‘Til next year!
February 24, 2025 at 3:42 PM
Reposted by Candie Paulsen Lab
Suffragists famously wore white as a symbol of purity, morality, and the quest for equality.

My sartorial decision to wear (mostly) white at #BPS2025 was meant as a reminder of the ongoing fight for gender equality and the importance of continued advocacy for women’s rights.
#womeninscience
February 18, 2025 at 8:55 PM
We are delighted to share the next story from the Paulsen lab! In a team effort led by Candie's first Yale grad student, Justin Sanders, we've uncovered a critical role for calmodulin in the TRPA1 pain receptor's calcium regulation. Check it out here: www.biorxiv.org/content/10.1...
December 13, 2024 at 8:52 PM