Paul Coletti
paulcoletti.bsky.social
Paul Coletti
@paulcoletti.bsky.social
Join me in the fight to end ALS
www.iamals.org/give/

I write about Notre Dame #ndwbb
irishalert.substack.com

NYC
I mean 20:46 to 3:21 time of possession is otherworldly
November 28, 2025 at 3:21 AM
ALS is not an incurable disease. It is an underfunded one.

Please, please consider making a donation this Giving Tuesday.

Together we can make ALS a liveable disease and eventually, cure it.
November 25, 2025 at 5:11 PM
Anyone can get this disease. They have identified some genetic variants, but the vast majority of ALS is sporadic. It is rare, but you will at some point in your life meet someone whose life has been seriously affected by ALS in either themselves or a loved one.
November 25, 2025 at 5:11 PM
The rate of research is increasing to search for a cause and to develop effective treatments. If they found the cause of the disease, they could definitely cure it. Only now, 150+ years after it was first described, are they uncovering some biomarkers that appear on blood tests and brain scans.
November 25, 2025 at 5:11 PM
Still, it's not enough. The only universally approved drug for ALS was approved way back in 1995 and extends time to death very modestly, about three months on average. Subsequently approved treatments are either for targeted subpopulations or have been withdrawn from the market for ineffectiveness.
November 25, 2025 at 5:11 PM
But the medical community's research into this disease is as relentless as the disease itself. There has been a profoundly hopeful uptick in drug discovery since the Ice Bucket Challenge. Clinical trials have become way more robust and drugs have novel targets within the mechanisms of the disease.
November 25, 2025 at 5:11 PM
There is no known cure for ALS. It claims the lives of its victims on average 2–5 years after symptom onset. Sometimes you start limping one month and within a year you cannot move. Stephen Hawking was a huge exception; Lou Gherig only lived for 23 months after diagnosis, which is much more typical.
November 25, 2025 at 5:11 PM
When you hear "ALS," it should strike fear into your heart. The Ice Bucket Challenge raised a lot of funds last decade, but the disease rages on, relentlessly locking its victims in their own body until they cannot move, speak, eat, and ultimately, breathe. It's horrifying.
November 25, 2025 at 5:11 PM