Patricia Skowronek
patiskowronek.bsky.social
Patricia Skowronek
@patiskowronek.bsky.social
AI & Proteomics Researcher @ MannLab - Max Planck Institute | PhD Biochemistry | Bioinformatics | Mass Spectrometry Expert | Automating complex workflows in life sciences
🔍 AI-assisted error detection: By comparing a video of an experiment to the baseline protocol, our agent detects common mistakes. It found 3/4 of all errors in our benchmark dataset, though domain-specific knowledge & spatial recognition need improvement. #GenerativeAI #QualityControl 3/🧵
October 8, 2025 at 7:59 PM
✍️ Automated protocol generation: Just record yourself doing an experiment while explaining the steps. Our agent analyzes the video and audio to generate a detailed, formatted protocol in minutes. #MultimodalAI #FutureOfScience 2/🧵
October 8, 2025 at 7:59 PM
🛠️ Meet py_diAID on GitHub: Our open-source #python tool that makes dia-PASEF & synchro-PASEF method development easy! Optimize your windows for any sample type - from #proteomics over #phosphoproteomics to #peptidomics #HLA. Validate methods before running or transform your own method into a GIF 5/🧵
January 20, 2025 at 8:49 PM
⚡️ synchro-PASEF: Our newest scan mode uses a super-fast moving quadrupole for high selectivity with up to precursor resolution - keeping all advantages of DDA & DIA. Result: 2-3x faster cycle times than dia-PASEF (only 500ms) AND superior quantitative reproducibility. #synchroPASEF #DIA 4/🧵
January 20, 2025 at 8:49 PM
dia-PASEF: Optimal DIA isolation windows in both m/z AND ion mobility space maximize precursor coverage. Our optimized methods capture nearly the entire precursor cloud in shorter cycle times - giving you a robust method with deep proteomes. #diaPASEF #DIA 3/🧵
January 20, 2025 at 8:49 PM
#PASEF 's magic: By decoupling ion accumulation from mass detection, PASEF captures nearly ALL ions with high sensitivity. Plus, ion mobility separation gives you cleaner spectra by sorting precursors & fragments in an extra dimension. Less overlapping peaks! #timsTOF #Bruker 2/🧵
January 20, 2025 at 8:49 PM