Pasha Davoudian
@pashadavoudian.bsky.social
md-phd student at yale | psychiatry, neuroscience | he/him
https://medicine.yale.edu/profile/pasha_davoudian/
https://medicine.yale.edu/profile/pasha_davoudian/
Reposted by Pasha Davoudian
New preprint + thread 🧵
#Psychedelics induce the formation of new synapses, but where do they connect?
Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.
www.biorxiv.org/content/10.1...
1/12
#Psychedelics induce the formation of new synapses, but where do they connect?
Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.
www.biorxiv.org/content/10.1...
1/12
August 7, 2025 at 2:49 PM
New preprint + thread 🧵
#Psychedelics induce the formation of new synapses, but where do they connect?
Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.
www.biorxiv.org/content/10.1...
1/12
#Psychedelics induce the formation of new synapses, but where do they connect?
Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.
www.biorxiv.org/content/10.1...
1/12
Reposted by Pasha Davoudian
People have warned about #psychedelics and 5-HT2B receptor activation for years — citing potential cardiotoxicity.
But no one had tested it. Until now. We used echocardiography to assess cardiac risk after chronic LSD microdosing in mice.
@sthom003.bsky.social
www.biorxiv.org/content/10.1...
But no one had tested it. Until now. We used echocardiography to assess cardiac risk after chronic LSD microdosing in mice.
@sthom003.bsky.social
www.biorxiv.org/content/10.1...
Assessing the potential cardiovascular risk of microdosing the psychedelic LSD in mice
Microdosing, the prolonged ingestion of psychedelics at sub-hallucinogenic doses, has gained popularity for its perceived cognitive and emotional benefits. Psychedelics have high affinity for 5-HT2B r...
www.biorxiv.org
April 14, 2025 at 1:12 PM
People have warned about #psychedelics and 5-HT2B receptor activation for years — citing potential cardiotoxicity.
But no one had tested it. Until now. We used echocardiography to assess cardiac risk after chronic LSD microdosing in mice.
@sthom003.bsky.social
www.biorxiv.org/content/10.1...
But no one had tested it. Until now. We used echocardiography to assess cardiac risk after chronic LSD microdosing in mice.
@sthom003.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Pasha Davoudian
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
www.nature.com
April 2, 2025 at 4:09 PM
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Reposted by Pasha Davoudian
Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊
Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.
Paper here 👇
www.nature.com/articles/s41...
Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.
Paper here 👇
www.nature.com/articles/s41...
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression - Nature Communications
A challenge in psychiatric drug discovery is to predict the therapeutic potential of a novel compound. Here, the authors show that brain-wide imaging of immediate early gene expression can be used to ...
www.nature.com
February 13, 2025 at 3:51 PM
Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊
Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.
Paper here 👇
www.nature.com/articles/s41...
Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.
Paper here 👇
www.nature.com/articles/s41...
Reposted by Pasha Davoudian
On tonight: Given that classical #psychedelics are 5-HT2B agonists, there is concern of a potential cardiovascular risk with prolonged use. To resemble human context, we chronically administered 2 low doses of LSD and performed echocardiograms at baseline, 4-, and 8-weeks. #ACNP2024
December 11, 2024 at 3:07 PM
On tonight: Given that classical #psychedelics are 5-HT2B agonists, there is concern of a potential cardiovascular risk with prolonged use. To resemble human context, we chronically administered 2 low doses of LSD and performed echocardiograms at baseline, 4-, and 8-weeks. #ACNP2024
Reposted by Pasha Davoudian
Look forward to #ACNP2024 🧠💊☀️
I am glad to organize a Tuesday panel with @bita137.bsky.social on "Manipulation of aversive events and memories by psychedelics"
Followed by Tuesday posters by current and past lab members @pashadavoudian.bsky.social and Sarah Jefferson
I am glad to organize a Tuesday panel with @bita137.bsky.social on "Manipulation of aversive events and memories by psychedelics"
Followed by Tuesday posters by current and past lab members @pashadavoudian.bsky.social and Sarah Jefferson
December 6, 2024 at 4:39 PM
Look forward to #ACNP2024 🧠💊☀️
I am glad to organize a Tuesday panel with @bita137.bsky.social on "Manipulation of aversive events and memories by psychedelics"
Followed by Tuesday posters by current and past lab members @pashadavoudian.bsky.social and Sarah Jefferson
I am glad to organize a Tuesday panel with @bita137.bsky.social on "Manipulation of aversive events and memories by psychedelics"
Followed by Tuesday posters by current and past lab members @pashadavoudian.bsky.social and Sarah Jefferson