They want validation with another orthogonal method; we are on it!

Thank you! Glad that you liked it 😊

This project is spec(at)ial for us: the 1️⃣ dataset generated by our team @cnag-eu.bsky.social using the very first CosMx SMI instrument installed worldwide 🎇, and in collaboration with 🥇 @elias campo & team 🥇 @idibaps.bsky.social

🔔 In scRNAseq, the top5 subpopulations (lymphos, basically follicular cells) = 97% of cells.
🚨 In CosMx SMI @brukerspatial.bsky.social ) these = 70%.
✍🏽 Spatial reveals epi & stromal diversity (but also immune tissue resident subsets), giving a much more faithful view of tissue composition.

🎇We resolve ~2M cells into 52 subpopulations across immune, epi & stromal compartments.
⁉️We interrogate cell-cell communication by modelling 181 signalling pairs at the niche- & subpopulation-level.

That is the link that the authors were explicitly asked to share with colleagues & friends 🫣 Anyhow, I removed it. Thx!

Conceptualised by
@hoheyn.bsky.social @jasmineplummer.bsky.social @lgmartelotto.bsky.social

Brought to life by Emanuele Pitino, Felipe Segato Dezem, Kellie Wise, Irepan Salvador Martinez, @helucro.bsky.social, Max Ruiz, Juan Nieto Sachica, Ginevra Caratu and more! 🎇🙏🏽👏🏽