Pascal Grumbach
@pascal-grumbach.bsky.social
Almost MD | Interested in multimodal neuroimaging of psychiatric disorders
This paper was part of my medical doctoral thesis. I would like to especially thank @juergendukart.bsky.social for the excellent supervision and all co-authors for their valuable support: @leoschilbach.bsky.social @sbe.bsky.social @sofievalk.bsky.social
September 17, 2025 at 12:28 PM
This paper was part of my medical doctoral thesis. I would like to especially thank @juergendukart.bsky.social for the excellent supervision and all co-authors for their valuable support: @leoschilbach.bsky.social @sbe.bsky.social @sofievalk.bsky.social
4) Specifically, ketamine reduced functional activity in those regions of the default mode network where it was also reduced in autism.
September 17, 2025 at 12:28 PM
4) Specifically, ketamine reduced functional activity in those regions of the default mode network where it was also reduced in autism.
3) Administration of NMDA-antagonist ketamine in healthy controls resembled functional alterations and neurochemical co-localization profiles observed in autism. Thus, pharmacological modulation of the excitation/inhibition in healthy individuals leads to similar brain patterns as seen in autism.
September 17, 2025 at 12:28 PM
3) Administration of NMDA-antagonist ketamine in healthy controls resembled functional alterations and neurochemical co-localization profiles observed in autism. Thus, pharmacological modulation of the excitation/inhibition in healthy individuals leads to similar brain patterns as seen in autism.
2) The consistent functional alterations in autism co-localized with distinct neurotransmitter properties, including glutamatergic (NMDA, mGluR5) and GABAergic (GABAa) neurotransmission.
September 17, 2025 at 12:28 PM
2) The consistent functional alterations in autism co-localized with distinct neurotransmitter properties, including glutamatergic (NMDA, mGluR5) and GABAergic (GABAa) neurotransmission.
1) Individuals with autism showed consistent local functional activity decreases compared to typically developed controls across ABIDE1/2, especially in default mode network regions.
September 17, 2025 at 12:28 PM
1) Individuals with autism showed consistent local functional activity decreases compared to typically developed controls across ABIDE1/2, especially in default mode network regions.