Parker Denz, PhD
@parkerjdenz.bsky.social
PhD in Biomedical Sciences | Ohio State alumni
Reposted by Parker Denz, PhD
A minireview from @parkerjdenz.bsky.social just out in @mbio.bsky.social! We explore why studies on IFITM3 SNPs and viral disease severity often conflict. Summary: IFITM3 matters most during infections with emergent viruses, when adaptive immunity is lacking. journals.asm.org/doi/10.1128/...
IFITM3 variants point to a critical role in emergent virus infections | mBio
The interferon-induced transmembrane protein (IFITM) family includes five IFITMs in
humans (IFITM1, 2, 3, 5, and 10). Each of these displays antiviral activity when overexpressed,
but only IFITMs 1, 2...
journals.asm.org
April 16, 2025 at 3:23 PM
A minireview from @parkerjdenz.bsky.social just out in @mbio.bsky.social! We explore why studies on IFITM3 SNPs and viral disease severity often conflict. Summary: IFITM3 matters most during infections with emergent viruses, when adaptive immunity is lacking. journals.asm.org/doi/10.1128/...
Reposted by Parker Denz, PhD
🚨Our new preprint! IFITM3 KO mice accelerated SARS-CoV-2 Beta & Omicron adaptation, preserving human-relevant traits & enabling comparative pathology/transcriptomics in mice. 🫁🦠🧬🥼 With @parkerjdenz.bsky.social, @adforu.bsky.social & team. 🔗 www.biorxiv.org/content/10.1...
January 29, 2025 at 3:17 PM
🚨Our new preprint! IFITM3 KO mice accelerated SARS-CoV-2 Beta & Omicron adaptation, preserving human-relevant traits & enabling comparative pathology/transcriptomics in mice. 🫁🦠🧬🥼 With @parkerjdenz.bsky.social, @adforu.bsky.social & team. 🔗 www.biorxiv.org/content/10.1...
Reposted by Parker Denz, PhD
🚨🚨 Our latest paper shows that IFITM3 deficiency lowers the minimum virus dose threshold for influenza and also enhances adaptation of the virus to a new species.🦠🫁 Major implications for preventing new pandemics. 😷 Proud of first author Parker Denz!👨🔬 www.nature.com/articles/s41...
Innate immune control of influenza virus interspecies adaptation via IFITM3 - Nature Communications
This study highlights that IFITM3 deficiency lowers the minimum infectious dose of influenza virus, enhances adaptation of influenza viruses to a new host species, and broadly increases infection of h...
www.nature.com
October 30, 2024 at 3:31 PM
🚨🚨 Our latest paper shows that IFITM3 deficiency lowers the minimum virus dose threshold for influenza and also enhances adaptation of the virus to a new species.🦠🫁 Major implications for preventing new pandemics. 😷 Proud of first author Parker Denz!👨🔬 www.nature.com/articles/s41...
Reposted by Parker Denz, PhD
I've officially made it as a virologist! TWiV discussed our latest paper!! 😱 www.microbe.tv/twiv/twiv-11...
TWiV 1165: What doesn't kill us primes our macrophages
TWiV notes the passing of virologist Diane Griffin, first H5N1 influenza virus in US pigs, Innate immune control of influenza virus interspecies adaptation via IFITM3, and antiviral trained innate imm...
www.microbe.tv
November 11, 2024 at 3:26 AM
I've officially made it as a virologist! TWiV discussed our latest paper!! 😱 www.microbe.tv/twiv/twiv-11...