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These findings not only show an interesting functional dissociation along the hipp. long axis, but also highlight the value of network-driven, domain-agnostic explorations of hippocampal function for identifying surprising findings, like the Posterior-SAL hipp. sensitivity to transient salience.

In a surprising contrast, the Posterior-SAL hipp. region was not primarily sensitive to scene construction, instead showing activity in response to salient stimuli (A & B below) and task transitions (C & D below), despite these tasks having no obvious declarative or associative memory demands.

Activity within hipp. regions closely resembled that of their partner cerebral network.

The Anterior-DN showed increased activity when participants were asked to imagine their future, and in particular was driven by the process of scene construction (see work from @laurendinicola.bsky.social).

In 20 extensively scanned participants (Discovery n = 11, Replication n = 9), we segmented the hippocampus based on differential functional connectivity to two cerebral networks, identifying distinct Anterior-DN and Posterior-SAL hippocampal regions (following the lead of Zheng et al. 2021).