Pajtler Lab
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pajtlerlab.bsky.social
Pajtler Lab
@pajtlerlab.bsky.social
Working on Reverse Translation and Adolescent & Young Adult Cancer at the Hopp Children's Cancer Center Heidelberg
We are excited to share our latest work highlighting the potential of liquid biopsies for pediatric CNS tumor patients - just published in Acta Neuropathologica Communications! Thank you to everyone who contributed to this study! doi.org/10.1186/s404... #LiquidBiopsy #cfDNA #PediatricNeuroOncology
Ultra-low-input cell-free DNA sequencing for tumor detection and characterization in a real-world pediatric brain tumor cohort - Acta Neuropathologica Communications
Molecular profiling of pediatric central nervous system (CNS) tumors has important clinical utility for guiding diagnostic and therapeutic strategies. Cell-free DNA (cfDNA) from liquid biopsies has be...
doi.org
July 2, 2025 at 3:06 PM
We had the privilege of presenting at this year’s Pediatric Neuro-Oncology Conference in San Diego. It was great to share our research and connect with friends and future collaborators dedicated to improving outcomes for children with brain tumors. #PediatricNeuroOncology #TeamScience #SNOPeds2025
May 23, 2025 at 7:45 PM
Thanks to the #Eureka Institute and @sickkidsto.bsky.social for hosting an amazing Translational Medicine Course and turning Tom Fischer and Leonhard Bamberg into newly baked #Eurekans! Loved it in Toronto!
May 5, 2025 at 8:01 PM
Paper on the challenges of hydrophobic drugs in cerebral microdialysis accepted to #CTSJournal, #ASCPTJournalFamily Based on own data + intensive literature review, we developed a decision tree to guide future studies in testing unspecific binding prior to microdialysis: doi.org/10.1111/cts....
Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates
Cerebral microdialysis in rodents represents a robust and versatile technique for quantifying the pharmacologically relevant unbound fraction of drugs in the brain. When this unbound fraction is simu...
doi.org
May 4, 2025 at 6:15 PM