@paddymonahan.bsky.social
#LongCovid Patient | Founder @ Circular Health - building tools for complex illness recovery http://joincircular.com
Want to join our early beta and be part of building a free community platform to help other complex illness patients? Sign up at joincircular.com and I'll send you an invite on Monday :-)
Circular Health - Find effective treatments for complex illness
Circular Health helps patients with complex illnesses like Long Covid, ME/CFS, POTS, MCAS and more find effective treatments based on the latest science, what's happening in the community and input fr...
joincircular.com
June 7, 2025 at 10:30 AM
Want to join our early beta and be part of building a free community platform to help other complex illness patients? Sign up at joincircular.com and I'll send you an invite on Monday :-)
The first ~1,000 anonymised treatment reviews are now live again. Thousands more are on the way.
Big thanks to the original team for trusting us to help preserve this for the community.
Big thanks to the original team for trusting us to help preserve this for the community.
June 7, 2025 at 10:30 AM
The first ~1,000 anonymised treatment reviews are now live again. Thousands more are on the way.
Big thanks to the original team for trusting us to help preserve this for the community.
Big thanks to the original team for trusting us to help preserve this for the community.
6/ Thanks to
@CallumThomas96
@DrMark_Faghy
@DerbyUni
@StellenboschUni
@JanPretorius98
@dbkell.bsky.social
@drmassimonunes
for this amazing work!
@CallumThomas96
@DrMark_Faghy
@DerbyUni
@StellenboschUni
@JanPretorius98
@dbkell.bsky.social
@drmassimonunes
for this amazing work!
May 28, 2025 at 11:17 AM
6/ Thanks to
@CallumThomas96
@DrMark_Faghy
@DerbyUni
@StellenboschUni
@JanPretorius98
@dbkell.bsky.social
@drmassimonunes
for this amazing work!
@CallumThomas96
@DrMark_Faghy
@DerbyUni
@StellenboschUni
@JanPretorius98
@dbkell.bsky.social
@drmassimonunes
for this amazing work!
5/ Why this matters
One of the clearest explanations of PEM to date. It shows that even gentle exercise can trigger clot fragmentation and inflammation. This should be another wake-up call for those still pushing blanket Graded Exercise Therapy.
One of the clearest explanations of PEM to date. It shows that even gentle exercise can trigger clot fragmentation and inflammation. This should be another wake-up call for those still pushing blanket Graded Exercise Therapy.
May 28, 2025 at 11:17 AM
5/ Why this matters
One of the clearest explanations of PEM to date. It shows that even gentle exercise can trigger clot fragmentation and inflammation. This should be another wake-up call for those still pushing blanket Graded Exercise Therapy.
One of the clearest explanations of PEM to date. It shows that even gentle exercise can trigger clot fragmentation and inflammation. This should be another wake-up call for those still pushing blanket Graded Exercise Therapy.
4/ What they found
- Large microclots fragmented into smaller ones
- Inflammation markers surged post-exercise
- Oxygen delivery got worse on Day2
Pointing to vascular injury+systemic inflammation, even from modest exertion. Matching what many patients experience after activity
- Large microclots fragmented into smaller ones
- Inflammation markers surged post-exercise
- Oxygen delivery got worse on Day2
Pointing to vascular injury+systemic inflammation, even from modest exertion. Matching what many patients experience after activity
May 28, 2025 at 11:17 AM
4/ What they found
- Large microclots fragmented into smaller ones
- Inflammation markers surged post-exercise
- Oxygen delivery got worse on Day2
Pointing to vascular injury+systemic inflammation, even from modest exertion. Matching what many patients experience after activity
- Large microclots fragmented into smaller ones
- Inflammation markers surged post-exercise
- Oxygen delivery got worse on Day2
Pointing to vascular injury+systemic inflammation, even from modest exertion. Matching what many patients experience after activity
3/ How was it done?
Participants did two submaximal cardiopulmonary exercise tests (CPETs), a common way to assess exercise tolerance. They chose participants who had a low risk of PEM. (imagine how bad this is for those with severe PEM)
Participants did two submaximal cardiopulmonary exercise tests (CPETs), a common way to assess exercise tolerance. They chose participants who had a low risk of PEM. (imagine how bad this is for those with severe PEM)
May 28, 2025 at 11:17 AM
3/ How was it done?
Participants did two submaximal cardiopulmonary exercise tests (CPETs), a common way to assess exercise tolerance. They chose participants who had a low risk of PEM. (imagine how bad this is for those with severe PEM)
Participants did two submaximal cardiopulmonary exercise tests (CPETs), a common way to assess exercise tolerance. They chose participants who had a low risk of PEM. (imagine how bad this is for those with severe PEM)
2/ What did they do?
46 people with Long COVID (low risk of PEM) did two gentle exercise tests, 24hrs apart.
They analysed:
– Microclot size & count
– Inflammatory cytokines
– Oxygen uptake
Aiming see how the body reacts after activity, not just during
46 people with Long COVID (low risk of PEM) did two gentle exercise tests, 24hrs apart.
They analysed:
– Microclot size & count
– Inflammatory cytokines
– Oxygen uptake
Aiming see how the body reacts after activity, not just during
May 28, 2025 at 11:17 AM
2/ What did they do?
46 people with Long COVID (low risk of PEM) did two gentle exercise tests, 24hrs apart.
They analysed:
– Microclot size & count
– Inflammatory cytokines
– Oxygen uptake
Aiming see how the body reacts after activity, not just during
46 people with Long COVID (low risk of PEM) did two gentle exercise tests, 24hrs apart.
They analysed:
– Microclot size & count
– Inflammatory cytokines
– Oxygen uptake
Aiming see how the body reacts after activity, not just during