@pablotaboas.bsky.social
Reposted
The new findings of Alina Ritter showcase that this approach may be especially feasible for metastatic disease since an impirtant viral docking site is highly expressed in metastatic lesions and even contributes to metastasis in #Ewing #sarcoma.
We will not stop until there is a cure!
We will not stop until there is a cure!
August 11, 2025 at 6:45 AM
Reposted
Based on the neomorphic DNA-binding capabilities of the Ewing sarcoma-specific EWSR1::ETS fusion oncoproteins, our expression constructs can deliver specifically produg convertases, (neo)-antigens, and cytokines to induce cell death only in Ewing cells, i.e. turn a 'cold' tumor 'hot'.
August 11, 2025 at 6:43 AM
Based on the neomorphic DNA-binding capabilities of the Ewing sarcoma-specific EWSR1::ETS fusion oncoproteins, our expression constructs can deliver specifically produg convertases, (neo)-antigens, and cytokines to induce cell death only in Ewing cells, i.e. turn a 'cold' tumor 'hot'.
Reposted
Since CXADR is a viral receptor, this study further paves the way for our novel virotherapy of #Ewing #sarcoma based on our 2022 study by @hoelting.bsky.social pioneering a suicde gene therapy induced by a Ewing sarcoma-specifc synthetic GGAA-enhancer
tinyurl.com/2sckk89m
tinyurl.com/2sckk89m
Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma - Molecular Cancer
Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Des...
tinyurl.com
August 11, 2025 at 6:41 AM
Since CXADR is a viral receptor, this study further paves the way for our novel virotherapy of #Ewing #sarcoma based on our 2022 study by @hoelting.bsky.social pioneering a suicde gene therapy induced by a Ewing sarcoma-specifc synthetic GGAA-enhancer
tinyurl.com/2sckk89m
tinyurl.com/2sckk89m