Oscar Yanes
@oyanes.bsky.social
Biochemist lost in a department of electronic engineering. #Metabolomics whisperer. Turning molecules into data and chaos into science.
7/ Compared to spray-coating, LTE shows:
✔️ Improved ionization
✔️ Reduced analyte diffusion
✔️ Better image sharpness
✔️ Cleaner baseline
8/ LTE pushes the boundaries of matrix deposition for MALDI-MSI. Better control, better data, better images. #MALDI #MassSpec #MSI #Metabolomics #Lipidomics
✔️ Improved ionization
✔️ Reduced analyte diffusion
✔️ Better image sharpness
✔️ Cleaner baseline
8/ LTE pushes the boundaries of matrix deposition for MALDI-MSI. Better control, better data, better images. #MALDI #MassSpec #MSI #Metabolomics #Lipidomics
April 22, 2025 at 8:37 AM
7/ Compared to spray-coating, LTE shows:
✔️ Improved ionization
✔️ Reduced analyte diffusion
✔️ Better image sharpness
✔️ Cleaner baseline
8/ LTE pushes the boundaries of matrix deposition for MALDI-MSI. Better control, better data, better images. #MALDI #MassSpec #MSI #Metabolomics #Lipidomics
✔️ Improved ionization
✔️ Reduced analyte diffusion
✔️ Better image sharpness
✔️ Cleaner baseline
8/ LTE pushes the boundaries of matrix deposition for MALDI-MSI. Better control, better data, better images. #MALDI #MassSpec #MSI #Metabolomics #Lipidomics
5/ LTE purifies the matrix during deposition — great for improving signal-to-noise, even when starting with lower-purity matrix
6/ The matrix stays stable at −80°C for at least 2 weeks. No loss in ionization efficiency or image quality after storage — big win for throughput & experimental planning
6/ The matrix stays stable at −80°C for at least 2 weeks. No loss in ionization efficiency or image quality after storage — big win for throughput & experimental planning
April 22, 2025 at 8:34 AM
5/ LTE purifies the matrix during deposition — great for improving signal-to-noise, even when starting with lower-purity matrix
6/ The matrix stays stable at −80°C for at least 2 weeks. No loss in ionization efficiency or image quality after storage — big win for throughput & experimental planning
6/ The matrix stays stable at −80°C for at least 2 weeks. No loss in ionization efficiency or image quality after storage — big win for throughput & experimental planning
3/ We validated LTE using two matrices:
✅ DHB
✅ DAN
Calibrated thickness vs. deposition time = ✔️ reproducibility.
4/ ESEM images showed beautiful, uniform sub-micron matrix crystals across the tissue. Small crystals = better ionization = sharper images.
✅ DHB
✅ DAN
Calibrated thickness vs. deposition time = ✔️ reproducibility.
4/ ESEM images showed beautiful, uniform sub-micron matrix crystals across the tissue. Small crystals = better ionization = sharper images.
April 22, 2025 at 8:30 AM
3/ We validated LTE using two matrices:
✅ DHB
✅ DAN
Calibrated thickness vs. deposition time = ✔️ reproducibility.
4/ ESEM images showed beautiful, uniform sub-micron matrix crystals across the tissue. Small crystals = better ionization = sharper images.
✅ DHB
✅ DAN
Calibrated thickness vs. deposition time = ✔️ reproducibility.
4/ ESEM images showed beautiful, uniform sub-micron matrix crystals across the tissue. Small crystals = better ionization = sharper images.
2/ Our solution to reduce this problem: #ChemEmbed
We combine enhanced MS/MS spectra with continuous vector representations of molecular structures (300-dimensional embeddings aligned with Mol2vec representations). This gives our CNN-based model richer input, improving annotation accuracy.
We combine enhanced MS/MS spectra with continuous vector representations of molecular structures (300-dimensional embeddings aligned with Mol2vec representations). This gives our CNN-based model richer input, improving annotation accuracy.
February 11, 2025 at 12:21 PM
2/ Our solution to reduce this problem: #ChemEmbed
We combine enhanced MS/MS spectra with continuous vector representations of molecular structures (300-dimensional embeddings aligned with Mol2vec representations). This gives our CNN-based model richer input, improving annotation accuracy.
We combine enhanced MS/MS spectra with continuous vector representations of molecular structures (300-dimensional embeddings aligned with Mol2vec representations). This gives our CNN-based model richer input, improving annotation accuracy.
Spray-coating is the most popular method, but LTE outperforms it by:
🔹 Enhancing ionization efficiency
🔹 Reducing analyte diffusion
🔹 Improving spatial resolution & image quality in MSI images
🔹 Enhancing ionization efficiency
🔹 Reducing analyte diffusion
🔹 Improving spatial resolution & image quality in MSI images
January 9, 2025 at 10:13 PM
Spray-coating is the most popular method, but LTE outperforms it by:
🔹 Enhancing ionization efficiency
🔹 Reducing analyte diffusion
🔹 Improving spatial resolution & image quality in MSI images
🔹 Enhancing ionization efficiency
🔹 Reducing analyte diffusion
🔹 Improving spatial resolution & image quality in MSI images
Stability is another win! After storing mouse brain sections coated with DHB or DAN matrices at -80 °C for two weeks, ionization efficiency, signal intensity, and image quality remained consistent. Robustness is crucial for long-term studies, and LTE delivers.
January 9, 2025 at 10:12 PM
Stability is another win! After storing mouse brain sections coated with DHB or DAN matrices at -80 °C for two weeks, ionization efficiency, signal intensity, and image quality remained consistent. Robustness is crucial for long-term studies, and LTE delivers.