Owen Randlett
@owenrandlett.bsky.social
Neuroscience, zebrafish, group leader at MeLiS Institute Lyon France.
Indeed, we think it could be!
February 7, 2025 at 12:34 PM
Indeed, we think it could be!
Surprisingly (at least to us!), we observed that some mutants actually habituate a bit more than their sibling controls when exposed to estradiol. So, we think these receptors do influence habituation—but they weakly suppress it, rather than promote it.
February 6, 2025 at 9:57 AM
Surprisingly (at least to us!), we observed that some mutants actually habituate a bit more than their sibling controls when exposed to estradiol. So, we think these receptors do influence habituation—but they weakly suppress it, rather than promote it.
This is unexpected but not unheard of, and has been observed in a few other contexts. @clot1.bsky.social 's group recently reported a similar finding on thrombosis in zebrafish:
doi.org/10.1101/2024....
We think there is another critical estradiol target that awaits characterization.
doi.org/10.1101/2024....
We think there is another critical estradiol target that awaits characterization.
Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafish
Venous thrombosis is a well-known complication of sex hormone therapy, with onset typically within weeks to months after initiation. Worldwide, more than 100 million pre-menopausal women use combined ...
doi.org
February 6, 2025 at 9:57 AM
This is unexpected but not unheard of, and has been observed in a few other contexts. @clot1.bsky.social 's group recently reported a similar finding on thrombosis in zebrafish:
doi.org/10.1101/2024....
We think there is another critical estradiol target that awaits characterization.
doi.org/10.1101/2024....
We think there is another critical estradiol target that awaits characterization.
To test this we used mutants generated by @danielgorelick.bsky.social ‘s lab. Disappointingly, we found that none of the receptors were necessary. We spent the next few years combining mutants to test for redundancy, but we concluded that none of these receptors promote habituation.
February 6, 2025 at 9:57 AM
To test this we used mutants generated by @danielgorelick.bsky.social ‘s lab. Disappointingly, we found that none of the receptors were necessary. We spent the next few years combining mutants to test for redundancy, but we concluded that none of these receptors promote habituation.
This follows up on a hit from our drug screen showing that estradiol increases habituation: doi.org/10.7554/eLif... . We expected this effect would be mediated by one of the known estrogen receptors—ERα, ERβ, or the G protein-coupled receptor Gper1.
Functional and pharmacological analyses of visual habituation learning in larval zebrafish
Complex and distributed plasticity processes are revealed by a functional and pharmacological analysis of visual habituation learning in larval zebrafish.
doi.org
February 6, 2025 at 9:57 AM
This follows up on a hit from our drug screen showing that estradiol increases habituation: doi.org/10.7554/eLif... . We expected this effect would be mediated by one of the known estrogen receptors—ERα, ERβ, or the G protein-coupled receptor Gper1.