Owen Marshall
@owenmarshall.bsky.social
Principal Research Fellow at the Menzies Institute for Medical Research, University of Tasmania
Leads a research group investigating the epigenetics and transcriptional regulation of neural development and disease
https://www.marshall-lab.org
Leads a research group investigating the epigenetics and transcriptional regulation of neural development and disease
https://www.marshall-lab.org
2/ Expression patterns of "pan-neuronal" drivers aren't as uniform as you'd think.
- elav[C155]-GAL4: Strong bias for mushroom body, weak in optic lobes.
- nSyb[R57C10]-GAL4: More consistent, but still regionally biased.
- ChAT-GAL4: Highly dynamic early on.
- elav[C155]-GAL4: Strong bias for mushroom body, weak in optic lobes.
- nSyb[R57C10]-GAL4: More consistent, but still regionally biased.
- ChAT-GAL4: Highly dynamic early on.
March 19, 2025 at 4:10 AM
2/ Expression patterns of "pan-neuronal" drivers aren't as uniform as you'd think.
- elav[C155]-GAL4: Strong bias for mushroom body, weak in optic lobes.
- nSyb[R57C10]-GAL4: More consistent, but still regionally biased.
- ChAT-GAL4: Highly dynamic early on.
- elav[C155]-GAL4: Strong bias for mushroom body, weak in optic lobes.
- nSyb[R57C10]-GAL4: More consistent, but still regionally biased.
- ChAT-GAL4: Highly dynamic early on.
1/ The GAL4/UAS system is a cornerstone of Drosophila neuroscience. But how stable are GAL4 drivers during aging?
We found that all tested drivers—elav[C155]-GAL4, nSyb[R57C10]-GAL4, ChAT-GAL4, and repo-GAL4—show rapid declines in activity over time.
We found that all tested drivers—elav[C155]-GAL4, nSyb[R57C10]-GAL4, ChAT-GAL4, and repo-GAL4—show rapid declines in activity over time.
March 19, 2025 at 4:10 AM
1/ The GAL4/UAS system is a cornerstone of Drosophila neuroscience. But how stable are GAL4 drivers during aging?
We found that all tested drivers—elav[C155]-GAL4, nSyb[R57C10]-GAL4, ChAT-GAL4, and repo-GAL4—show rapid declines in activity over time.
We found that all tested drivers—elav[C155]-GAL4, nSyb[R57C10]-GAL4, ChAT-GAL4, and repo-GAL4—show rapid declines in activity over time.