Otavio Ranzani
@otavioranzani.bsky.social
Group Leader - DataHealth Lab
Global Health | Epidemiology | RCTs
Critical Care, Infections, Climate Change
#DecolonizeGH 🇧🇷
At IR Sant Pau, Barcelona / USP, São Paulo
https://datahealthlab.org
Global Health | Epidemiology | RCTs
Critical Care, Infections, Climate Change
#DecolonizeGH 🇧🇷
At IR Sant Pau, Barcelona / USP, São Paulo
https://datahealthlab.org
Thanks to all group team working on it, collaborators and the São Paulo State Health Secretary.
September 18, 2025 at 9:12 AM
Thanks to all group team working on it, collaborators and the São Paulo State Health Secretary.
The protection was 50% (45−55) after the first dose and 62% (40−76) after the second dose against symptomatic Dengue, and 68% (43-81) after the first dose against hospitalization.
Several sensitivity analysis were comparable to these results.
Several sensitivity analysis were comparable to these results.
September 18, 2025 at 9:12 AM
The protection was 50% (45−55) after the first dose and 62% (40−76) after the second dose against symptomatic Dengue, and 68% (43-81) after the first dose against hospitalization.
Several sensitivity analysis were comparable to these results.
Several sensitivity analysis were comparable to these results.
DENV-1 and DENV-2 were the main circulating serotypes, but DENV-3 emerged more consistently by the end of year.
Because of low sample size, we could not conduct serotype-specific analysis for vaccine effectiveness.
Because of low sample size, we could not conduct serotype-specific analysis for vaccine effectiveness.
September 18, 2025 at 9:12 AM
DENV-1 and DENV-2 were the main circulating serotypes, but DENV-3 emerged more consistently by the end of year.
Because of low sample size, we could not conduct serotype-specific analysis for vaccine effectiveness.
Because of low sample size, we could not conduct serotype-specific analysis for vaccine effectiveness.
The outbreak and vaccine coverage among the 10-14y in 392 municipalites (n=2.4 million 10-14) of São Paulo State that were prioritized for vaccination because of high incidence of disease.
September 18, 2025 at 9:12 AM
The outbreak and vaccine coverage among the 10-14y in 392 municipalites (n=2.4 million 10-14) of São Paulo State that were prioritized for vaccination because of high incidence of disease.
Slack taking care of this summer over here and my brain get heated by coding this morning 😅
Stay Hydrated
#Slack #ClimateChange
Stay Hydrated
#Slack #ClimateChange
September 1, 2025 at 2:13 PM
Slack taking care of this summer over here and my brain get heated by coding this morning 😅
Stay Hydrated
#Slack #ClimateChange
Stay Hydrated
#Slack #ClimateChange
Our new work describing large cohort of Dengue pts admitted to ICUs in 🇧🇷
➡️11047 pts (~largest ICU data so far, 2012-2024)
➡️1117 admissions (10%) had complications during ICU stay (death, organ support, blood products transfusion)
➡️Description of LAC, WBC and PLTs
www.ijidonline.com/article/S120...
➡️11047 pts (~largest ICU data so far, 2012-2024)
➡️1117 admissions (10%) had complications during ICU stay (death, organ support, blood products transfusion)
➡️Description of LAC, WBC and PLTs
www.ijidonline.com/article/S120...
August 29, 2025 at 2:16 PM
Our new work describing large cohort of Dengue pts admitted to ICUs in 🇧🇷
➡️11047 pts (~largest ICU data so far, 2012-2024)
➡️1117 admissions (10%) had complications during ICU stay (death, organ support, blood products transfusion)
➡️Description of LAC, WBC and PLTs
www.ijidonline.com/article/S120...
➡️11047 pts (~largest ICU data so far, 2012-2024)
➡️1117 admissions (10%) had complications during ICU stay (death, organ support, blood products transfusion)
➡️Description of LAC, WBC and PLTs
www.ijidonline.com/article/S120...
Happy to share the new guideline on Fluids from the @esicm.bsky.social that I have contributed to and collaborated with amazing colleagues.
This is the Part-3 of the series tackling FLUID REMOVAL.
rdcu.be/eBwjF
@intenscaremed.bsky.social
#ICU
#Fluids
#Guidelines
@irsantpau.bsky.social
This is the Part-3 of the series tackling FLUID REMOVAL.
rdcu.be/eBwjF
@intenscaremed.bsky.social
#ICU
#Fluids
#Guidelines
@irsantpau.bsky.social
August 25, 2025 at 8:02 AM
Happy to share the new guideline on Fluids from the @esicm.bsky.social that I have contributed to and collaborated with amazing colleagues.
This is the Part-3 of the series tackling FLUID REMOVAL.
rdcu.be/eBwjF
@intenscaremed.bsky.social
#ICU
#Fluids
#Guidelines
@irsantpau.bsky.social
This is the Part-3 of the series tackling FLUID REMOVAL.
rdcu.be/eBwjF
@intenscaremed.bsky.social
#ICU
#Fluids
#Guidelines
@irsantpau.bsky.social
Happy to share our piece on Whats's New in Intensive Care
where we integrate allostasis, allostatic overload and pallitiave care
At @intenscaremed.bsky.social
rdcu.be/eyDiA
where we integrate allostasis, allostatic overload and pallitiave care
At @intenscaremed.bsky.social
rdcu.be/eyDiA
August 2, 2025 at 1:20 PM
Happy to share our piece on Whats's New in Intensive Care
where we integrate allostasis, allostatic overload and pallitiave care
At @intenscaremed.bsky.social
rdcu.be/eyDiA
where we integrate allostasis, allostatic overload and pallitiave care
At @intenscaremed.bsky.social
rdcu.be/eyDiA
July 16, 2025 at 12:24 PM
Happy to share our contribution to the Standard of Care in the Intensive Care Unit at @intenscaremed.bsky.social
rdcu.be/epImu
rdcu.be/epImu
June 8, 2025 at 5:13 PM
Happy to share our contribution to the Standard of Care in the Intensive Care Unit at @intenscaremed.bsky.social
rdcu.be/epImu
rdcu.be/epImu
Ever heard of BRICNET?
It’s the Brazilian Network for Critical Care Research—born in 2007 from a driven group of colleagues. Since then, it’s grown into a global force in critical care science.
Proud to be part of this journey!
🚀 #BRICNET
criticalcarescience.org/article/braz...
It’s the Brazilian Network for Critical Care Research—born in 2007 from a driven group of colleagues. Since then, it’s grown into a global force in critical care science.
Proud to be part of this journey!
🚀 #BRICNET
criticalcarescience.org/article/braz...
May 25, 2025 at 10:23 AM
Ever heard of BRICNET?
It’s the Brazilian Network for Critical Care Research—born in 2007 from a driven group of colleagues. Since then, it’s grown into a global force in critical care science.
Proud to be part of this journey!
🚀 #BRICNET
criticalcarescience.org/article/braz...
It’s the Brazilian Network for Critical Care Research—born in 2007 from a driven group of colleagues. Since then, it’s grown into a global force in critical care science.
Proud to be part of this journey!
🚀 #BRICNET
criticalcarescience.org/article/braz...
Peri-intubation adverse events: #BARCO study
- 18 centres in 🇧🇷
- 2846 patients
- Major adverse events in 919 (32.3%) intubations:
- Mainly: new hemodynamic instability (20.0%), severe hypoxemia (12.5%) and cardiac arrest (3.5%).
Many other insights here:
ccforum.biomedcentral.com/articles/10....
- 18 centres in 🇧🇷
- 2846 patients
- Major adverse events in 919 (32.3%) intubations:
- Mainly: new hemodynamic instability (20.0%), severe hypoxemia (12.5%) and cardiac arrest (3.5%).
Many other insights here:
ccforum.biomedcentral.com/articles/10....
May 14, 2025 at 7:30 AM
Peri-intubation adverse events: #BARCO study
- 18 centres in 🇧🇷
- 2846 patients
- Major adverse events in 919 (32.3%) intubations:
- Mainly: new hemodynamic instability (20.0%), severe hypoxemia (12.5%) and cardiac arrest (3.5%).
Many other insights here:
ccforum.biomedcentral.com/articles/10....
- 18 centres in 🇧🇷
- 2846 patients
- Major adverse events in 919 (32.3%) intubations:
- Mainly: new hemodynamic instability (20.0%), severe hypoxemia (12.5%) and cardiac arrest (3.5%).
Many other insights here:
ccforum.biomedcentral.com/articles/10....
Congratulations to my amazing PhD student, Amanda, for defending brilliantly her thesis!
A pleasure to co-supervise you throughout this journey!
A pleasure to co-supervise you throughout this journey!
April 16, 2025 at 11:07 AM
Congratulations to my amazing PhD student, Amanda, for defending brilliantly her thesis!
A pleasure to co-supervise you throughout this journey!
A pleasure to co-supervise you throughout this journey!
Our viewpoint on Common Pitfalls in Critical Care Research just published on #criticalcarescience
criticalcarescience.org/article/comm...
criticalcarescience.org/article/comm...
April 6, 2025 at 6:12 PM
Our viewpoint on Common Pitfalls in Critical Care Research just published on #criticalcarescience
criticalcarescience.org/article/comm...
criticalcarescience.org/article/comm...
Very nice (and provocative) commentary on Blue Journal @atscommunity.bsky.social on Bayesian subgroup analysis of RCTs
www.atsjournals.org/doi/epdf/10....
www.atsjournals.org/doi/epdf/10....
April 6, 2025 at 5:03 PM
Very nice (and provocative) commentary on Blue Journal @atscommunity.bsky.social on Bayesian subgroup analysis of RCTs
www.atsjournals.org/doi/epdf/10....
www.atsjournals.org/doi/epdf/10....
Females and older were most affected. The overall association was robust to 3 sensitivity analyses, including one adjusting for the number of cases.
This short-term effect of heat on dengue severity matches the mechanisms of severe Dengue and heat (alterations on coagulation/dehidratation, etc).
This short-term effect of heat on dengue severity matches the mechanisms of severe Dengue and heat (alterations on coagulation/dehidratation, etc).
February 11, 2025 at 9:28 AM
Females and older were most affected. The overall association was robust to 3 sensitivity analyses, including one adjusting for the number of cases.
This short-term effect of heat on dengue severity matches the mechanisms of severe Dengue and heat (alterations on coagulation/dehidratation, etc).
This short-term effect of heat on dengue severity matches the mechanisms of severe Dengue and heat (alterations on coagulation/dehidratation, etc).
We evaluated a times series of 10y in Brazil, analysing ~580k Dengue hospitalisations and ambient temperature from ERA5-Land.
Using the #CaseTimesSeries design, we observed an ⬆️ risk in dengue hospitalisation across the country and each region. The shape of association was unclear at the North.
Using the #CaseTimesSeries design, we observed an ⬆️ risk in dengue hospitalisation across the country and each region. The shape of association was unclear at the North.
February 11, 2025 at 9:28 AM
We evaluated a times series of 10y in Brazil, analysing ~580k Dengue hospitalisations and ambient temperature from ERA5-Land.
Using the #CaseTimesSeries design, we observed an ⬆️ risk in dengue hospitalisation across the country and each region. The shape of association was unclear at the North.
Using the #CaseTimesSeries design, we observed an ⬆️ risk in dengue hospitalisation across the country and each region. The shape of association was unclear at the North.
Does heat have a short effect on Dengue, increasing risk for severe cases?
We know meteorological factors affect dengue incidence, with lag effects on weeks/months.
Here, led by @rafalpx.bsky.social, we found also a short effect of heat for Dengue Hospitalisation
journals.lww.com/environepide...
We know meteorological factors affect dengue incidence, with lag effects on weeks/months.
Here, led by @rafalpx.bsky.social, we found also a short effect of heat for Dengue Hospitalisation
journals.lww.com/environepide...
February 11, 2025 at 9:28 AM
Does heat have a short effect on Dengue, increasing risk for severe cases?
We know meteorological factors affect dengue incidence, with lag effects on weeks/months.
Here, led by @rafalpx.bsky.social, we found also a short effect of heat for Dengue Hospitalisation
journals.lww.com/environepide...
We know meteorological factors affect dengue incidence, with lag effects on weeks/months.
Here, led by @rafalpx.bsky.social, we found also a short effect of heat for Dengue Hospitalisation
journals.lww.com/environepide...
All regions of the country was affected. During some weeks, the number of admissions by hospital beds was higher for Influenza than Omicron (also see first figure).
December 7, 2024 at 10:35 AM
All regions of the country was affected. During some weeks, the number of admissions by hospital beds was higher for Influenza than Omicron (also see first figure).
Published in #PublicHealth, with great collaborators and lead by #Tarsila
@juliocroda.bsky.social @isglobal.org @uspoficial.bsky.social
@juliocroda.bsky.social @isglobal.org @uspoficial.bsky.social
December 7, 2024 at 10:35 AM
Published in #PublicHealth, with great collaborators and lead by #Tarsila
@juliocroda.bsky.social @isglobal.org @uspoficial.bsky.social
@juliocroda.bsky.social @isglobal.org @uspoficial.bsky.social
Ending 2021, Brazil had two outbreaks: its 1st Omicron wave and an out-of-season Influenza A H3N2
The burden was massive. Here we describe what happened in terms of strain in the system, patients, and clinically describe the co-infections:
www.sciencedirect.com/science/arti...
The burden was massive. Here we describe what happened in terms of strain in the system, patients, and clinically describe the co-infections:
www.sciencedirect.com/science/arti...
December 7, 2024 at 10:35 AM
Ending 2021, Brazil had two outbreaks: its 1st Omicron wave and an out-of-season Influenza A H3N2
The burden was massive. Here we describe what happened in terms of strain in the system, patients, and clinically describe the co-infections:
www.sciencedirect.com/science/arti...
The burden was massive. Here we describe what happened in terms of strain in the system, patients, and clinically describe the co-infections:
www.sciencedirect.com/science/arti...
Happy to share D-PRISM, a global survey on Diagnostic and treatment approaches on Pneumonias managed in the ICU, published in #CriticalCare
Very important points to foster advancements in the field.
Great group collaboration!
ccforum.biomedcentral.com/articles/10....
@andymoz78.bsky.social
Very important points to foster advancements in the field.
Great group collaboration!
ccforum.biomedcentral.com/articles/10....
@andymoz78.bsky.social
November 26, 2024 at 3:18 PM
Happy to share D-PRISM, a global survey on Diagnostic and treatment approaches on Pneumonias managed in the ICU, published in #CriticalCare
Very important points to foster advancements in the field.
Great group collaboration!
ccforum.biomedcentral.com/articles/10....
@andymoz78.bsky.social
Very important points to foster advancements in the field.
Great group collaboration!
ccforum.biomedcentral.com/articles/10....
@andymoz78.bsky.social
Really happy to share our editorial on Fludrocortisone on top of Hydrocortisone in Sepsis!
It was a pleasure to write it with two giants #Annane and #Singer on such an important trial #FLuDress.
rdcu.be/d0cZx
It was a pleasure to write it with two giants #Annane and #Singer on such an important trial #FLuDress.
rdcu.be/d0cZx
November 14, 2024 at 2:01 PM
Really happy to share our editorial on Fludrocortisone on top of Hydrocortisone in Sepsis!
It was a pleasure to write it with two giants #Annane and #Singer on such an important trial #FLuDress.
rdcu.be/d0cZx
It was a pleasure to write it with two giants #Annane and #Singer on such an important trial #FLuDress.
rdcu.be/d0cZx