The future of Alzheimer's treatment could very well be gene therapy.

A subtype, PDE4B, was recently found to be implicated in Alzheimer's and its inhibition in an App knock-in mouse model potentially having a protective effect.

#Alzheimers, #dementia, #aging
tinyurl.com/27eejhdj

NAD, and NMN could all potentially reverse aging. So far, though, no dice.

Trigonelline, an NAD+ precursor, was recently found to improve muscle function in skeletal muscle. And continued good muscle function can potentially extend life.

#aging, #longevity, #olderadults
tinyurl.com/3xjhx5we

Studies that state the obvious are great. Like a recent JAMA article that said sitting less reduces blood pressure in older adults.

Wait, sitting on our asses for long periods of time is bad?

tinyurl.com/bdyd5nv6

Genetic clusters susceptible to Alzheimer's are influenced by 3 main modifiable risk factors: Diabetes, air pollution and alcohol intake.

This doesn't bode well for places like India, Bangladesh and Pakistan where air pollution is real bad.

#Alzheimers, #dementia, #aging
tinyurl.com/3adapb4w

Opioids for pain relief are preferred in older adults to NSAIDS like Ibuprofen.

A new study recently showed, though, that they can increase risk for serious falls, especially in >85 years old.

Use with caution.

#olderadults, #opioids, #falls
tinyurl.com/zrpx654x

Soon, we may live in a world where we mass produce Alzheimer's medication through fermentation.

Amaryllidaceae alkaloids are useful in Alzheimer's treatment but difficult to mass produce.

Enter fermentation. High yield. Low difficulty.

#Alzheimers, #aging, #dementia
tinyurl.com/nrhebmt6

Remember these genes: OARD1/NFYA/TREML1, JAZF1, FERMT2, and SLC24A4.

Just roll off the tongue, don't they?

An analysis of whole genome sequence data implicated these genes in Alzheimer's, which is good for possible future treatments.

#dementia, #Alzheimers, #aging
tinyurl.com/44au6b8n

Excess thyroid hormone can possibly exacerbate cognitive decline in older adults.

This is important, especially when prescribing Levothyroxine in older adults since we tend to want to ensure thyroid hormone numbers are perfect.

#olderadult, #aging, #thyroid, #thyroidhormone
tinyurl.com/pe2c6yaj

It's not that HBO's "The Last of Us" is closer to being a reality but there ARE an alarming number of fungal species with multi-drug resistance currently in the world, according to a new study.

Nothing to worry about, right? 😟

#lastofus, #fungus, #hbo, #medicine
tinyurl.com/bdsm887w

Intermittent fasting? Turns out, not so great. At least the 8 hour window version.

The 8 hour window version can increase cardiovascular risk by 91%!

Is this definitive? Not exactly but sheesh, 91% increased risk.

#fasting, #heart, #cardiovascular, #heartdisease
tinyurl.com/bde79r73

Novel ways of detecting early dementia are always interesting.

A new study used 24-hour rest/activity rhythms and found there were noticeable differences in preclinical amyloid beta positive patients compared to negative patients.

#dementia, #aging, #Alzheimers
tinyurl.com/yfzbnzfz

Why does everyone think taking Rifampicin will make them live forever? NMN, Metformin, Rifampicin? Is this what anti-aging is right now? Taking 200 supplements Bryan Johnson-style and hope something works? No thanks.

Having said that, I'm definitely taking it.

#antiaging, #olderadults, #aging

For most people, dementia = memory loss.

But what if before that, there are issues with language processing?

Patients with early signs of dementia show problems with syntax-semantics interface.

#aging, #dementia, #Alzheimers, #olderadults
tinyurl.com/46ntyuf6