Olivier Mathieu
@oliviermathieu.bsky.social
Biologist studying the molecular bases of epigenetics
Research Director @CNRS @cnrs.bsky.social
Group leader @iGReD_Clermont
Research Director @CNRS @cnrs.bsky.social
Group leader @iGReD_Clermont
Cool and neat story led by my former PhD student @p-bourguet.bsky.social Congrats Pierre and crew!! www.nature.com/articles/s41...
Major alleles of CDCA7 shape CG methylation in Arabidopsis thaliana - Nature Plants
This genome-wide association study identifies CELL DIVISION CYCLE-ASSOCIATED PROTEIN 7 (CDCA7) as a regulator of DNA methylation in natural Arabidopsis thaliana populations. CDCA7 binds the chromatin ...
www.nature.com
November 10, 2025 at 11:27 AM
Cool and neat story led by my former PhD student @p-bourguet.bsky.social Congrats Pierre and crew!! www.nature.com/articles/s41...
Reposted by Olivier Mathieu
A TE insertion controls throat colour in wheatears. The gene involved (ASIP) is the same one that is epigenetically affected by an IAP insertion the famous Avy mice.
As if we needed more reasons to love TEs.
As if we needed more reasons to love TEs.
A mosaic of modular variation at a single gene underpins convergent plumage coloration
The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...
www.science.org
October 17, 2025 at 11:43 AM
A TE insertion controls throat colour in wheatears. The gene involved (ASIP) is the same one that is epigenetically affected by an IAP insertion the famous Avy mice.
As if we needed more reasons to love TEs.
As if we needed more reasons to love TEs.
Reposted by Olivier Mathieu
#ResultatScientifique 🔎 L'équilibre entre activation et répression des gènes est crucial pour le développement et chez les plantes ils existent des protéines "gardiennes" de ce mécanisme !
✍️ O. Mathieu & G. Moissiard
👉 L'article dans @natplants.nature.com
buff.ly/v7R7mbj
✍️ O. Mathieu & G. Moissiard
👉 L'article dans @natplants.nature.com
buff.ly/v7R7mbj
Des protéines « gardiennes » préservent l’expression des gènes chez les plantes
Chez les organismes multicellulaires, l'équilibre entre l’activation et la répression des gènes est crucial pour le développement.
www.insb.cnrs.fr
October 3, 2025 at 3:00 PM
#ResultatScientifique 🔎 L'équilibre entre activation et répression des gènes est crucial pour le développement et chez les plantes ils existent des protéines "gardiennes" de ce mécanisme !
✍️ O. Mathieu & G. Moissiard
👉 L'article dans @natplants.nature.com
buff.ly/v7R7mbj
✍️ O. Mathieu & G. Moissiard
👉 L'article dans @natplants.nature.com
buff.ly/v7R7mbj
Our paper is finally out in Nature Plants. MAIL proteins antagonize Polycomb-mediated silencing. Full text here: rdcu.be/eJisX
Plant mobile domain protein–DNA motif modules counteract Polycomb silencing to stabilize gene expression
Nature Plants - This study reveals that plant proteins MAIL1, MAIN and MAIL2 function as anti-silencing factors that maintain active gene expression. They bind specific DNA motifs to prevent...
rdcu.be
October 6, 2025 at 6:35 AM
Our paper is finally out in Nature Plants. MAIL proteins antagonize Polycomb-mediated silencing. Full text here: rdcu.be/eJisX
Reposted by Olivier Mathieu
Last good news from 2024!
Our latest paper on TE-derived small RNAs is finally out! It reveals a beautiful buffering mechanism involving epigenetics, chromatin organization, and pathogen resistance. A great collaboration with @plantevolution.bsky.social, don’t miss it!
www.nature.com/articles/s41...
Our latest paper on TE-derived small RNAs is finally out! It reveals a beautiful buffering mechanism involving epigenetics, chromatin organization, and pathogen resistance. A great collaboration with @plantevolution.bsky.social, don’t miss it!
www.nature.com/articles/s41...
December 30, 2024 at 1:44 PM
Last good news from 2024!
Our latest paper on TE-derived small RNAs is finally out! It reveals a beautiful buffering mechanism involving epigenetics, chromatin organization, and pathogen resistance. A great collaboration with @plantevolution.bsky.social, don’t miss it!
www.nature.com/articles/s41...
Our latest paper on TE-derived small RNAs is finally out! It reveals a beautiful buffering mechanism involving epigenetics, chromatin organization, and pathogen resistance. A great collaboration with @plantevolution.bsky.social, don’t miss it!
www.nature.com/articles/s41...
Reposted by Olivier Mathieu
📣 #EMBOMobileGenome is open for registrations!
Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍
📜 Submit abstract by 29 July!
👉🏼 https://s.embl.org/mge25-01-bl
Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍
📜 Submit abstract by 29 July!
👉🏼 https://s.embl.org/mge25-01-bl
January 27, 2025 at 3:13 PM
📣 #EMBOMobileGenome is open for registrations!
Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍
📜 Submit abstract by 29 July!
👉🏼 https://s.embl.org/mge25-01-bl
Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍
📜 Submit abstract by 29 July!
👉🏼 https://s.embl.org/mge25-01-bl
Reposted by Olivier Mathieu
In our latest @biorxiv-genomic.bsky.social preprint, we describe our approach to use PacBio HiFi reads to detect somatic TE transposition -- good enough to detect rare events that are present in only single cells. Led by Andrea Movilli.
#plantscience
www.biorxiv.org/content/10.1...
#plantscience
www.biorxiv.org/content/10.1...
February 10, 2025 at 10:57 AM
In our latest @biorxiv-genomic.bsky.social preprint, we describe our approach to use PacBio HiFi reads to detect somatic TE transposition -- good enough to detect rare events that are present in only single cells. Led by Andrea Movilli.
#plantscience
www.biorxiv.org/content/10.1...
#plantscience
www.biorxiv.org/content/10.1...
while Plants == Mammals:
use(H3K4me3, mode="anti-DNA methylation", target="Arabidopsis")
www.nature.com/articles/s41...
use(H3K4me3, mode="anti-DNA methylation", target="Arabidopsis")
www.nature.com/articles/s41...
Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis - Nature Plants
This study revealed that targeting H3K4me3 via the H3K4 methyltransferase SDG2 activates gene expression and removes DNA methylation by recruiting DNA demethylases. Conversely, the removal of H3K4me3 ...
www.nature.com
February 13, 2025 at 9:24 AM
while Plants == Mammals:
use(H3K4me3, mode="anti-DNA methylation", target="Arabidopsis")
www.nature.com/articles/s41...
use(H3K4me3, mode="anti-DNA methylation", target="Arabidopsis")
www.nature.com/articles/s41...