Olivia Goldman PhD
@oliviagoldman.net
Schmidt Science & Weill Neurohub Postdoctoral Fellow in neuroimmunology & bioinformatics | SENse Lab @berkeleymcb.bsky.social | PhD in the deadliest animal 🦟 | Co-founder & Board Secretary @cientificolatino.com 💗 | she/her 🏳️🌈
Check out the Aedes aegypti Mosquito Cell Atlas for yourself!! Acessible from your web browser thanks to @genomebrowser.bsky.social & @ucscgenomics.bsky.social!!
If you have a min to report to us what your favorite gene looks like, we would love to hear about it 😃✨
mosquito.cells.ucsc.edu
If you have a min to report to us what your favorite gene looks like, we would love to hear about it 😃✨
mosquito.cells.ucsc.edu
October 30, 2025 at 5:03 PM
Check out the Aedes aegypti Mosquito Cell Atlas for yourself!! Acessible from your web browser thanks to @genomebrowser.bsky.social & @ucscgenomics.bsky.social!!
If you have a min to report to us what your favorite gene looks like, we would love to hear about it 😃✨
mosquito.cells.ucsc.edu
If you have a min to report to us what your favorite gene looks like, we would love to hear about it 😃✨
mosquito.cells.ucsc.edu
This project was truly a testament to collaborative science. It was such a pleasure to learn from and exchange perspectives with scientists from >15 insect labs across the globe while we interpreted this complex dataset.
Thank you to all our contributors!
8/n
Thank you to all our contributors!
8/n
March 5, 2025 at 5:54 PM
This project was truly a testament to collaborative science. It was such a pleasure to learn from and exchange perspectives with scientists from >15 insect labs across the globe while we interpreted this complex dataset.
Thank you to all our contributors!
8/n
Thank you to all our contributors!
8/n
Bloodfeeding triggers dramatic physiological & behavioral changes in female mosquitoes. We looked in the brain after feeding to understand which cellular substrates might underlie this shift.
Unexpectedly, our data highlight the glia as possible mediators of this change!
6/n
Unexpectedly, our data highlight the glia as possible mediators of this change!
6/n
![Bar plot of number of differentially expressed genes between blood feeding conditions and sugar-fed female brain, per cell type. Bars colored by blood feeding condition. Glia and neuron cell types listed below bars. Genes thresholded on |log fold change| > 1 and false discovery rate (fdr) < 0.05 (determined by MAST on normalized expression, which is ln([(raw count/total cell counts)x median total counts across cells]+1)).](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:wtyt5buymgxkqigidgq76ce5/bafkreicowyup3nfr4gydvhynhpl46jrf7ge7msjtfrl4ihiffjkpekw75a@jpeg)
March 5, 2025 at 5:54 PM
Bloodfeeding triggers dramatic physiological & behavioral changes in female mosquitoes. We looked in the brain after feeding to understand which cellular substrates might underlie this shift.
Unexpectedly, our data highlight the glia as possible mediators of this change!
6/n
Unexpectedly, our data highlight the glia as possible mediators of this change!
6/n
Chemoreceptor gene expression is surprisingly similar between sexes across sensory organs.
We found a precise exception. Previously we reported that Ir41l cells in the female antenna express Or82. Males have the same cell type, but without the Or82 receptor.
5/n
We found a precise exception. Previously we reported that Ir41l cells in the female antenna express Or82. Males have the same cell type, but without the Or82 receptor.
5/n
March 5, 2025 at 5:54 PM
Chemoreceptor gene expression is surprisingly similar between sexes across sensory organs.
We found a precise exception. Previously we reported that Ir41l cells in the female antenna express Or82. Males have the same cell type, but without the Or82 receptor.
5/n
We found a precise exception. Previously we reported that Ir41l cells in the female antenna express Or82. Males have the same cell type, but without the Or82 receptor.
5/n
We previously saw an unexpected degree of chemoreceptor gene family co-expression in the antenna (Herre, Goldman, et al. 2022).
The tarsi and proboscis also demonstrate co-expression in specific cell types - even across sensory modalities, such as sweet taste & heat!
4/n
The tarsi and proboscis also demonstrate co-expression in specific cell types - even across sensory modalities, such as sweet taste & heat!
4/n
March 5, 2025 at 5:54 PM
We previously saw an unexpected degree of chemoreceptor gene family co-expression in the antenna (Herre, Goldman, et al. 2022).
The tarsi and proboscis also demonstrate co-expression in specific cell types - even across sensory modalities, such as sweet taste & heat!
4/n
The tarsi and proboscis also demonstrate co-expression in specific cell types - even across sensory modalities, such as sweet taste & heat!
4/n
Only female bloodfeed & there are extreme differences in sensory biology across mosquito sexes. We provide insights to the cellular & molecular basis of this sexual dimorphism.
For example, we discovered a completely undescribed male-specific cell type in the male antenna.
3/n
For example, we discovered a completely undescribed male-specific cell type in the male antenna.
3/n
March 5, 2025 at 5:54 PM
Only female bloodfeed & there are extreme differences in sensory biology across mosquito sexes. We provide insights to the cellular & molecular basis of this sexual dimorphism.
For example, we discovered a completely undescribed male-specific cell type in the male antenna.
3/n
For example, we discovered a completely undescribed male-specific cell type in the male antenna.
3/n
Mosquitoes spread viruses to >400 million people/year.
Importantly, our work led to a complete parts list of gene expression. This will help develop hypotheses & spur discoveries into the unique biology of the mosquito.
mosquito.cells.ucsc.edu
Thank you UCSC Cell Browser team!
2/n
Importantly, our work led to a complete parts list of gene expression. This will help develop hypotheses & spur discoveries into the unique biology of the mosquito.
mosquito.cells.ucsc.edu
Thank you UCSC Cell Browser team!
2/n
March 5, 2025 at 5:54 PM
Mosquitoes spread viruses to >400 million people/year.
Importantly, our work led to a complete parts list of gene expression. This will help develop hypotheses & spur discoveries into the unique biology of the mosquito.
mosquito.cells.ucsc.edu
Thank you UCSC Cell Browser team!
2/n
Importantly, our work led to a complete parts list of gene expression. This will help develop hypotheses & spur discoveries into the unique biology of the mosquito.
mosquito.cells.ucsc.edu
Thank you UCSC Cell Browser team!
2/n
I am thrilled to present the Mosquito Cell Atlas! We analyzed 367K nuclei from 19 tissues in male & female mosquitoes, creating a comprehensive resource for vector biology & infectious disease research.
Plus we made some surprising discoveries! 🦟🧵
biorxiv.org/content/10.1...
1/n
Plus we made some surprising discoveries! 🦟🧵
biorxiv.org/content/10.1...
1/n
March 5, 2025 at 5:54 PM
I am thrilled to present the Mosquito Cell Atlas! We analyzed 367K nuclei from 19 tissues in male & female mosquitoes, creating a comprehensive resource for vector biology & infectious disease research.
Plus we made some surprising discoveries! 🦟🧵
biorxiv.org/content/10.1...
1/n
Plus we made some surprising discoveries! 🦟🧵
biorxiv.org/content/10.1...
1/n