Oli Hale
@olijhale.bsky.social
Infrequently posting cycling, science and wildlife stuff.
It also seems impressively user-friendly. The new nanoESI source will be popular.
November 6, 2025 at 7:56 PM
It also seems impressively user-friendly. The new nanoESI source will be popular.
I thought I just couldn’t find the correct stream… but no, more nickel and diming. Wasn’t the sub price increase enough? Time to cancel.
July 5, 2025 at 4:52 PM
I thought I just couldn’t find the correct stream… but no, more nickel and diming. Wasn’t the sub price increase enough? Time to cancel.
Never mind: found what I was after at the end of the “timsOmni-ebook”.
“<4500 m/z quadrupole isolation in transmission mode and 150 to >10,000 m/z omni-Q2 isolaton in trapping mode”
“<4500 m/z quadrupole isolation in transmission mode and 150 to >10,000 m/z omni-Q2 isolaton in trapping mode”
June 1, 2025 at 8:43 PM
Never mind: found what I was after at the end of the “timsOmni-ebook”.
“<4500 m/z quadrupole isolation in transmission mode and 150 to >10,000 m/z omni-Q2 isolaton in trapping mode”
“<4500 m/z quadrupole isolation in transmission mode and 150 to >10,000 m/z omni-Q2 isolaton in trapping mode”
Are these specs actually in any documents? Seems to be a lot of missing info. Would love to know Q2 omnitrap isolation range and whether photo activation has to be added by the end user…
June 1, 2025 at 8:31 PM
Are these specs actually in any documents? Seems to be a lot of missing info. Would love to know Q2 omnitrap isolation range and whether photo activation has to be added by the end user…
I hope this thing is a monster. Looking forward to seeing how it is for membrane protein top-down MS especially.
May 30, 2025 at 9:43 PM
I hope this thing is a monster. Looking forward to seeing how it is for membrane protein top-down MS especially.
Conversely, it seems that Waters are implementing a heated ion transfer tube on their ELIT CDMS (I would usually associate this inlet type with Thermo) and Bruker are even using an SRIG for the front end of timsOmni. I think we’re just witnessing technological convergence and maturation.
April 23, 2025 at 1:09 PM
Conversely, it seems that Waters are implementing a heated ion transfer tube on their ELIT CDMS (I would usually associate this inlet type with Thermo) and Bruker are even using an SRIG for the front end of timsOmni. I think we’re just witnessing technological convergence and maturation.
Fascinating! I’m not able to make ASMS this year so I’ll be absorbing what I can online.
April 21, 2025 at 8:30 PM
Fascinating! I’m not able to make ASMS this year so I’ll be absorbing what I can online.
Any indication of isolation m/z limit on new “Exploris” with that m/z 12,000 detection range? And definitely ETD and not ECD?
April 21, 2025 at 8:16 PM
Any indication of isolation m/z limit on new “Exploris” with that m/z 12,000 detection range? And definitely ETD and not ECD?
Wouldn’t be surprised to finally see an Exploris UHMR.
March 6, 2025 at 8:54 AM
Wouldn’t be surprised to finally see an Exploris UHMR.
I remember your poster on this at… I think…IMSC 2022, Hamish! Cool to see it developed further. Was there any relation to this work and the curved IRM on Stellar?
February 26, 2025 at 9:15 PM
I remember your poster on this at… I think…IMSC 2022, Hamish! Cool to see it developed further. Was there any relation to this work and the curved IRM on Stellar?
Internal calibrant ion injection? I know on Ascend we get a reagent anion AGC check every 15 mins for PTCR MSn experiments.
February 20, 2025 at 7:21 PM
Internal calibrant ion injection? I know on Ascend we get a reagent anion AGC check every 15 mins for PTCR MSn experiments.
Miss the days of GCN+, I would have subscribed forever. Discovery+ at £6.99 was passable but this is a joke. Guess I’ll just stop watching and use the time to ride more myself.
January 31, 2025 at 9:43 PM
Miss the days of GCN+, I would have subscribed forever. Discovery+ at £6.99 was passable but this is a joke. Guess I’ll just stop watching and use the time to ride more myself.
For this project we literally pulled an LTQ Velos Pro off the front of a broken Orbitrap Elite and put the IRMPD laser from a decommissioned LTQ-FT onto it.
November 28, 2024 at 7:31 PM
For this project we literally pulled an LTQ Velos Pro off the front of a broken Orbitrap Elite and put the IRMPD laser from a decommissioned LTQ-FT onto it.
These pumps are AMAZING.
November 28, 2024 at 6:45 PM
These pumps are AMAZING.
High m/z isolation on the quadrupole is a game changer for our on-tissue native MS. It was the biggest thing missing from Eclipse from our perspective. Big performance uplift!
November 25, 2024 at 9:24 PM
High m/z isolation on the quadrupole is a game changer for our on-tissue native MS. It was the biggest thing missing from Eclipse from our perspective. Big performance uplift!