@uniquefergus.bsky.social

At nice n sleazy last night (a young person’s drinking haunt with a room below)

Are you supporting Coldplay?

😂

Although sad to see in bits, the saved stones of the Sir John Maxwell school gives an insight into "assembly by numbers"

@murphyniallgla.bsky.social

To be fair, the word is there. What I think is also important is the cooperative nature of the DNA-dependent TF:TF interactions, which give a much steeper response curve to [TF]. I wonder whether that's the big driver here, allowing more specificity in these more complex metazoan situations?

There's also a simple rule of base pairing for the tRNA:codon interaction. A TF:DNA interaction is a less exact process with more of a continuum of binding affinities to different sequences, making it more 'analog' (sensu Ball).

Awesome gig!

Is the issue here though that it’s trying to be non-technical, using natural language, but you think of other things that could be “the origin of human replication” iyswim?

In which case make it more obscure such as this:

www.nature.com/articles/s41...

The concept dates back to the late 1980's although the use of "licensing" and "licensing factor" (the whole MCM/CDC complex) came a bit later - here's Julian talking about it in 1995 in another (Nature) paper with licensing in the title :)

Your post placing on my feed 😳

Wow what’s going on there ? The way the light bends.