Nicholas Fabiano, MD
@ntfabiano.bsky.social
Writing about science
The minimal dose was 3.4 minutes per day for total (HR, 0.83; 95% CI, 0.73-0.93) and 3.7 minutes for PA-related (HR, 0.72; 95% CI, 0.59-0.88) cancer incidence. 8/10
December 9, 2024 at 1:15 PM
The minimal dose was 3.4 minutes per day for total (HR, 0.83; 95% CI, 0.73-0.93) and 3.7 minutes for PA-related (HR, 0.72; 95% CI, 0.59-0.88) cancer incidence. 8/10
These findings are from a study in JAMA Oncology which aimed to evaluate the dose-response association of device-measured daily vigorous intermittent lifestyle physical activity (VILPA) with incident cancer. jamanetwork.com/journals/jam... 2/10
December 9, 2024 at 1:15 PM
These findings are from a study in JAMA Oncology which aimed to evaluate the dose-response association of device-measured daily vigorous intermittent lifestyle physical activity (VILPA) with incident cancer. jamanetwork.com/journals/jam... 2/10
Just 3 to 4 minutes of vigorous physical activity per day is associated with decreased cancer risk.
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December 9, 2024 at 1:15 PM
Just 3 to 4 minutes of vigorous physical activity per day is associated with decreased cancer risk.
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A single glutamine to leucine mutation at residue 226 of the virus hemagglutinin was sufficient to enact the change from avian to human specificity. 7/9
December 7, 2024 at 1:07 PM
A single glutamine to leucine mutation at residue 226 of the virus hemagglutinin was sufficient to enact the change from avian to human specificity. 7/9
These findings are from a study in Science which performed a genetic and structural analysis of the H5N1 mutations necessary to fully switch host receptor recognition. www.science.org/doi/10.1126/... 2/9
December 7, 2024 at 1:07 PM
These findings are from a study in Science which performed a genetic and structural analysis of the H5N1 mutations necessary to fully switch host receptor recognition. www.science.org/doi/10.1126/... 2/9
We are one mutation away from human-to-human transmission of H5N1 (bird flu).
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December 7, 2024 at 1:07 PM
We are one mutation away from human-to-human transmission of H5N1 (bird flu).
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A pilot clinical study showed that DBSLH immediately improved walking in two participants with incomplete SCI and, in conjunction with rehabilitation, mediated functional recovery that persisted when DBSLH was turned off. 10/11
December 6, 2024 at 1:14 PM
A pilot clinical study showed that DBSLH immediately improved walking in two participants with incomplete SCI and, in conjunction with rehabilitation, mediated functional recovery that persisted when DBSLH was turned off. 10/11
This discovery was translated into a deep brain stimulation therapy of the LH (DBSLH) that immediately augmented walking in mice and rats with SCI and durably increased recovery through the reorganization of residual lumbar-terminating projections from brainstem neurons. 9/11
December 6, 2024 at 1:14 PM
This discovery was translated into a deep brain stimulation therapy of the LH (DBSLH) that immediately augmented walking in mice and rats with SCI and durably increased recovery through the reorganization of residual lumbar-terminating projections from brainstem neurons. 9/11
Specifically, it was found that glutamatergic neurons located in the LH (LHVglut2) contribute to the recovery of walking after incomplete SCI and that augmenting their activity improves walking. 8/11
December 6, 2024 at 1:14 PM
Specifically, it was found that glutamatergic neurons located in the LH (LHVglut2) contribute to the recovery of walking after incomplete SCI and that augmenting their activity improves walking. 8/11
Unexpectedly, interrogation of this atlas nominated the lateral hypothalamus (LH). 7/11
December 6, 2024 at 1:14 PM
Unexpectedly, interrogation of this atlas nominated the lateral hypothalamus (LH). 7/11
SCI scatters the communication between the brain and the neurons in the lumbar spinal cord that must be activated to produce walking. 3/11
December 6, 2024 at 1:14 PM
SCI scatters the communication between the brain and the neurons in the lumbar spinal cord that must be activated to produce walking. 3/11
These findings are from a study in Nature Medicine which aimed to identify brain regions that steer the recovery of walking after incomplete spinal cord injury (SCI). www.nature.com/articles/s41... 2/11
December 6, 2024 at 1:14 PM
These findings are from a study in Nature Medicine which aimed to identify brain regions that steer the recovery of walking after incomplete spinal cord injury (SCI). www.nature.com/articles/s41... 2/11
Deep brain stimulation allowed people to walk again after a spinal cord injury.
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December 6, 2024 at 1:14 PM
Deep brain stimulation allowed people to walk again after a spinal cord injury.
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When writing by hand, brain connectivity patterns were far more elaborate than when typewriting on a keyboard, as shown by widespread theta/alpha connectivity coherence patterns between network hubs and nodes in parietal and central brain regions. 6/10
December 4, 2024 at 12:37 PM
When writing by hand, brain connectivity patterns were far more elaborate than when typewriting on a keyboard, as shown by widespread theta/alpha connectivity coherence patterns between network hubs and nodes in parietal and central brain regions. 6/10
These findings are from a study in Frontiers in Psychology which recorded brain electrical activity in 36 university students as they were handwriting visually presented words using a digital pen and typewriting the words on a keyboard. www.frontiersin.org/journals/psy... 2/10
December 4, 2024 at 12:37 PM
These findings are from a study in Frontiers in Psychology which recorded brain electrical activity in 36 university students as they were handwriting visually presented words using a digital pen and typewriting the words on a keyboard. www.frontiersin.org/journals/psy... 2/10
Handwriting leads to widespread brain connectivity - typing does not.
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December 4, 2024 at 12:37 PM
Handwriting leads to widespread brain connectivity - typing does not.
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These findings are from our systematic review in European Neuropsychopharmacology which assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. www.sciencedirect.com/science/arti... 2/10
December 3, 2024 at 12:36 PM
These findings are from our systematic review in European Neuropsychopharmacology which assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. www.sciencedirect.com/science/arti... 2/10
We just published the largest study on sex-stratified mortality estimates in schizophrenia.
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December 3, 2024 at 12:36 PM
We just published the largest study on sex-stratified mortality estimates in schizophrenia.
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Vaccination reduced but did not eliminate spike protein accumulation after infection in mice. 9/10
December 1, 2024 at 1:29 PM
Vaccination reduced but did not eliminate spike protein accumulation after infection in mice. 9/10
Injection of spike protein alone was sufficient to induce neuroinflammation, proteome changes in the skull-meninges-brain axis, anxiety-like behavior, and exacerbated outcomes in mouse models of stroke and traumatic brain injury. 8/10
December 1, 2024 at 1:29 PM
Injection of spike protein alone was sufficient to induce neuroinflammation, proteome changes in the skull-meninges-brain axis, anxiety-like behavior, and exacerbated outcomes in mouse models of stroke and traumatic brain injury. 8/10
In this study, the accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients was observed, persisting long after viral clearance. 6/10
December 1, 2024 at 1:29 PM
In this study, the accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients was observed, persisting long after viral clearance. 6/10
The spike protein, one of the critical structural proteins of SARS-CoV-2 mediating cell entry, has been shown to affect endothelial function in vitro and in vivo inducing Toll-like receptor (TLR) 2 or TLR4-mediated inflammatory responses after systemic injection. 4/10
December 1, 2024 at 1:29 PM
The spike protein, one of the critical structural proteins of SARS-CoV-2 mediating cell entry, has been shown to affect endothelial function in vitro and in vivo inducing Toll-like receptor (TLR) 2 or TLR4-mediated inflammatory responses after systemic injection. 4/10
These findings are from a study in Cell Host & Microbe which used optical clearing and imaging to observe the accumulation of SARS-CoV-2 spike protein in human COVID-19 patients. www.cell.com/cell-host-mi... 2/10
December 1, 2024 at 1:29 PM
These findings are from a study in Cell Host & Microbe which used optical clearing and imaging to observe the accumulation of SARS-CoV-2 spike protein in human COVID-19 patients. www.cell.com/cell-host-mi... 2/10
The SARS-CoV-2 spike protein stays in the brain after a COVID-19 infection.
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December 1, 2024 at 1:29 PM
The SARS-CoV-2 spike protein stays in the brain after a COVID-19 infection.
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In this paper, we highlight the key factors to consider when prescribing physical activity for depression. econtent.hogrefe.com/doi/full/10.... 2/13
November 29, 2024 at 1:03 PM
In this paper, we highlight the key factors to consider when prescribing physical activity for depression. econtent.hogrefe.com/doi/full/10.... 2/13