Noemi Ezinne Nwosu
@noemi-n.bsky.social
PhD student @mutschlerlab.bsky.social
CRC 392 - Molecular Evolution in Prebiotic Environments
CRC 392 - Molecular Evolution in Prebiotic Environments
Working on this was a lot of fun!
Thank you for your guidance @szokoli.bsky.social ☺️✨
Thank you for your guidance @szokoli.bsky.social ☺️✨
Have you ever wanted to design large and complex ribozymes from scratch? I know I have!
We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins!
#intron #RNAsky #SynBio 🧬🧵(1/n)
We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins!
#intron #RNAsky #SynBio 🧬🧵(1/n)
Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes
Group II Introns (G2Is) are large self-splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2,...
doi.org
July 2, 2025 at 10:15 AM
Working on this was a lot of fun!
Thank you for your guidance @szokoli.bsky.social ☺️✨
Thank you for your guidance @szokoli.bsky.social ☺️✨