Noah Olsman
@noaholsman.bsky.social
Postdoc in synthetic biology in Johan Paulsson's lab at HMS SysBio. Trying to understanding feedback circuits in living cells by building them.
This paper argued a branch of cephalopods traded genome plasticity for the ability to edit their mRNA. This branch also happens to be the smart cephalopods! They don't go as far as saying the trade-off is what made them smart, but it is definitely implied.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Trade-off between transcriptome plasticity and genome evolution in cephalopods
RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals. Recent reports suggesting increased le...
pmc.ncbi.nlm.nih.gov
July 27, 2025 at 1:30 AM
This paper argued a branch of cephalopods traded genome plasticity for the ability to edit their mRNA. This branch also happens to be the smart cephalopods! They don't go as far as saying the trade-off is what made them smart, but it is definitely implied.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
At least in E coli, the terminators in this paper are the best I've found anywhere and have made a pretty massive difference in read through over even other synthetic terminators.
April 26, 2025 at 11:39 AM
At least in E coli, the terminators in this paper are the best I've found anywhere and have made a pretty massive difference in read through over even other synthetic terminators.
The man works magic the rest of us can only dream of
September 27, 2023 at 10:30 PM
The man works magic the rest of us can only dream of