I'll be presenting our latest work, that explores proteo-transcriptomic changes that occur with brain aging and their impact on protein synthesis at the #EMBLProtein conference.

If you want to know more about it, come and spin my poster #129.
#proteinsynthesis #brainaging

Our study provides an extensive resource on molecular aging, and offers insights into mechanisms predisposing to neurodegeneration, easily accessible at our Brain Aging and Molecular Atlas Project (BrainAging-MAP) website.

Analysis of the nine models revealed key similarities and differences between physiological aging and pathology.

Aggregation of 60S ribosome proteins indicates deteriorating translation efficiency and control. A tightening of the p/m coefficient with age suggests aging reduces regulatory capacity, increasing mRNA–protein correlation.

Decrease in mitochondrial complex I proteins were not compensated at the mRNA level.

We identified dynamic changes in physiological aging, highlighting differences in synaptic maintenance and energy-allocation.

Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain.

Co–first author with Verena Kluever. Grateful to @forna.bsky.social‬ for mentorship, and to @tatjanat.bsky.social‬, Carlos López Otín & all collaborators🧠

If that was the peak of my climb, then every grueling step—each hardship endured—prepared me for an extraordinary destiny!

Thanks to everyone who made this possible, especially @forna.bsky.social for your support and mentorship over the years!
@imprsgs.bsky.social #PhDone