Thanks Dafners. There is a gut angle here, so maybe you can give us some tips of what might be actually happening here!

Great @transmission-zero.bsky.social teamwork with @sebaldv.bsky.social taming the beast and Prashanth Selvaraj spinning up the model!

We need to know much more about the complex fitness effects we observe and how they would translate to the field.

Gene drives that affect vector longevity and induce bloodmeal-specific mortality are predicted to be highly effective in reducing malaria transmission as we show in our model.

Targeting ultraconserved RNA genes (like some naturally occurring HEGs do) is an alternative approach for pre-empting resistance (dancing around the degeneracy of the genetic code with multiple gRNAs just kicks the can down the road for protein coding genes).

It's target sire is conserved far beyond Diptera, and hence is present in Anopheles gambiae, arabiensis, coluzzii and funestus.

We describe (one of) the most promising gene drives for malaria control so far. This drive shows near perfect inheritance bias but doesn't fall neatly into the suppression/modification categories.