Thanks to Annika Bender, @miracnur.bsky.social and others who contributed 👏 #DNAm #BPD #epigentics

These findings suggest that PRDM8 methylation may be linked to BPD and its treatment response, highlighting the need for further research on its functional significance and gene-environment interactions in psychiatric disorders.

➡️ BPD patients showed PRDM8 hypomethylation compared to healthy controls.
➡️ After Dialectical Behavioral Therapy, methylation levels increased in line with reduced symptom severity.
➡️ No associations were found with adverse childhood experiences.

Join us on 10 and 11th of July at between 13:30 and 17:30 (CEST) at Psychiatry Research Building or register online at molpsych@med.uni-tuebingen.de to explore potential joint projects. See you there! #TRT2025 #unituebingen #UBA

To foster this exciting new partnership, we're holding a hybrid workshop to build collaborations between labs! This initiative is proudly supported by Tübingen Research Takeoff (TRT). @unituebingen.bsky.social

We found lower GDAP1 DNA methlyation and lower H3K4me3 level in patients with alcohol use disorder. H3K4me3 levels normalized after abstinence-based therapy, whereas DNA methylation levels remained unchanged. We could not find any differences in GDAP1 expression. #alcoholusedisorder #epigenetics