Nicolas Merle
nicolasmerle.bsky.social
Nicolas Merle
@nicolasmerle.bsky.social
Excited to share my first last-author paper! Using in vivo models, transcriptomic analyses, and cellular assays, we demonstrate that HCAR2 acts as a receptor for heme, potentially forming a novel negative feedback loop that promotes Hmox1 expression.
www.sciencedirect.com/science/arti...
HCAR2 is a novel receptor for heme
Extracellular heme, released during intravascular hemolysis in sickle cell disease (SCD) and hemolytic anemia acts as a pro-inflammatory danger signal…
www.sciencedirect.com
May 16, 2025 at 10:30 AM