Shyuan Ngo
@ngoshyuan.bsky.social
#PACTALS2025
Abstract submission deadline has been extended until March 17 - join us in #Melbourne #Australia this September!
Showcasing ALS research and care across the Asia-Pacific and hearing perspectives and updates from global colleagues
pactalscongress.com
@mndaus-research.bsky.social
Abstract submission deadline has been extended until March 17 - join us in #Melbourne #Australia this September!
Showcasing ALS research and care across the Asia-Pacific and hearing perspectives and updates from global colleagues
pactalscongress.com
@mndaus-research.bsky.social
March 2, 2025 at 4:23 AM
#PACTALS2025
Abstract submission deadline has been extended until March 17 - join us in #Melbourne #Australia this September!
Showcasing ALS research and care across the Asia-Pacific and hearing perspectives and updates from global colleagues
pactalscongress.com
@mndaus-research.bsky.social
Abstract submission deadline has been extended until March 17 - join us in #Melbourne #Australia this September!
Showcasing ALS research and care across the Asia-Pacific and hearing perspectives and updates from global colleagues
pactalscongress.com
@mndaus-research.bsky.social
We looked at the relationship between fatigue and metabolic rate in #ALS. Fatigue is a complex symptom - more needs to be done to understand how we can best address it.
@fredsteyn.bsky.social @ammaralchalabi.bsky.social
www.tandfonline.com/doi/full/10....
@fredsteyn.bsky.social @ammaralchalabi.bsky.social
www.tandfonline.com/doi/full/10....
Persistent high levels of perceived fatigue are not associated with hypermetabolism in patients with amyotrophic lateral sclerosis
Objective: Fatigue is a common symptom in amyotrophic lateral sclerosis (ALS). Little is known about factors that contribute to fatigue, and whether levels of fatigue change throughout disease cour...
www.tandfonline.com
March 2, 2025 at 3:28 AM
We looked at the relationship between fatigue and metabolic rate in #ALS. Fatigue is a complex symptom - more needs to be done to understand how we can best address it.
@fredsteyn.bsky.social @ammaralchalabi.bsky.social
www.tandfonline.com/doi/full/10....
@fredsteyn.bsky.social @ammaralchalabi.bsky.social
www.tandfonline.com/doi/full/10....
Reposted by Shyuan Ngo
Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf
rdcu.be/ebbZf
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...
rdcu.be
February 25, 2025 at 1:31 PM
Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf
rdcu.be/ebbZf
Our study on the safety and tolerability of Trimetazidine in #ALS @braincomms.bsky.social
Trimetazidine reduced oxidative stress markers and energy expenditure, warranting a follow up study
@rpavaneijk.bsky.social @fredsteyn.bsky.social @ammaralchalabi.bsky.social
academic.oup.com/braincomms/a...
Trimetazidine reduced oxidative stress markers and energy expenditure, warranting a follow up study
@rpavaneijk.bsky.social @fredsteyn.bsky.social @ammaralchalabi.bsky.social
academic.oup.com/braincomms/a...
February 10, 2025 at 10:10 AM
Our study on the safety and tolerability of Trimetazidine in #ALS @braincomms.bsky.social
Trimetazidine reduced oxidative stress markers and energy expenditure, warranting a follow up study
@rpavaneijk.bsky.social @fredsteyn.bsky.social @ammaralchalabi.bsky.social
academic.oup.com/braincomms/a...
Trimetazidine reduced oxidative stress markers and energy expenditure, warranting a follow up study
@rpavaneijk.bsky.social @fredsteyn.bsky.social @ammaralchalabi.bsky.social
academic.oup.com/braincomms/a...
Some new and interesting work on cell-free DNA in #ALS - insights into biomarker potential
link.springer.com/epdf/10.1186...
link.springer.com/epdf/10.1186...
Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons
link.springer.com
January 16, 2025 at 10:54 AM
Some new and interesting work on cell-free DNA in #ALS - insights into biomarker potential
link.springer.com/epdf/10.1186...
link.springer.com/epdf/10.1186...
A timely piece that everyone should read. There are many challenges but we have a responsibility to communicate outcomes without the over sensationalisation!
New paper to reflect on the main challenges in phase 2 #ALS #MND trials. Key issues relate too short study durations, reliance on the wrong outcome measures, absence of biomarkers, statistical issues, over-interpretation of 'clinical trends' and miscommunication. academic.oup.com/brain/articl...
Rethinking phase 2 trials in amyotrophic lateral sclerosis
There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria
academic.oup.com
December 12, 2024 at 11:45 AM
A timely piece that everyone should read. There are many challenges but we have a responsibility to communicate outcomes without the over sensationalisation!
Reposted by Shyuan Ngo
New paper to reflect on the main challenges in phase 2 #ALS #MND trials. Key issues relate too short study durations, reliance on the wrong outcome measures, absence of biomarkers, statistical issues, over-interpretation of 'clinical trends' and miscommunication. academic.oup.com/brain/articl...
Rethinking phase 2 trials in amyotrophic lateral sclerosis
There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria
academic.oup.com
December 10, 2024 at 3:14 PM
New paper to reflect on the main challenges in phase 2 #ALS #MND trials. Key issues relate too short study durations, reliance on the wrong outcome measures, absence of biomarkers, statistical issues, over-interpretation of 'clinical trends' and miscommunication. academic.oup.com/brain/articl...
Decision email received at 00:38 - how long does one hold off from logging on to see the bad news???
November 25, 2024 at 5:25 PM
Decision email received at 00:38 - how long does one hold off from logging on to see the bad news???
Reposted by Shyuan Ngo
LRP4 controls SO MUCH more! And it all seems to do so from the PRESYNAPSE (answering that HUGE open question). LRP4 controls synapse growth, cytoskeletal organization, postsynaptic protein recruitment, AND maturation. Multiple processes for the price of one cell surface protein!
November 9, 2023 at 12:34 AM
LRP4 controls SO MUCH more! And it all seems to do so from the PRESYNAPSE (answering that HUGE open question). LRP4 controls synapse growth, cytoskeletal organization, postsynaptic protein recruitment, AND maturation. Multiple processes for the price of one cell surface protein!
@ammaralchalabi.bsky.social It’s the Blue Sky Effect 😬
November 17, 2024 at 6:35 AM
@ammaralchalabi.bsky.social It’s the Blue Sky Effect 😬