Neurology Mainz
@neurologymainz.bsky.social
Neuroimmunology Research Groups, Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
https://www.unimedizin-mainz.de/neurologie/en/research/research-groups.html
https://www.unimedizin-mainz.de/neurologie/en/research/research-groups.html
Kicking off this year‘s annual DGN Congress in Berlin with an opening symposium focused on resilience, which included an engaging panel discussion. Looking forward to more interesting presentations over the next few days! #dgnkongress2025.
November 12, 2025 at 2:55 PM
Kicking off this year‘s annual DGN Congress in Berlin with an opening symposium focused on resilience, which included an engaging panel discussion. Looking forward to more interesting presentations over the next few days! #dgnkongress2025.
In our latest study, out now in Sci Transl Med, we show that B cell-released lymphotoxin-α impairs human neuronal activity, which is reversible upon BTK inhibitor treatment. Thank you to everyone involved in this exciting work! @science.org
Bruton’s tyrosine kinase inhibitors rescue neuronal impairment caused by B cell–mediated lymphotoxin-α release
Lymphotoxin-α release from B cells impairs neuronal activity in coculture models, which is reversible upon BTK inhibitor treatment.
www.science.org
October 30, 2025 at 12:03 PM
In our latest study, out now in Sci Transl Med, we show that B cell-released lymphotoxin-α impairs human neuronal activity, which is reversible upon BTK inhibitor treatment. Thank you to everyone involved in this exciting work! @science.org
Johannes and Natascha were happy for the opportunity to present their work at ISNI.
October 6, 2025 at 12:47 PM
Johannes and Natascha were happy for the opportunity to present their work at ISNI.
Lots of great talks so far at ISNI 2025!
October 6, 2025 at 5:12 AM
Lots of great talks so far at ISNI 2025!
Frauke Zipp giving the Keynote Lecture at the International Society for #Neuroimmunology in Chiba, Japan. We’re excited for several of our group members to be in Japan for this great meeting!
October 5, 2025 at 8:09 AM
Frauke Zipp giving the Keynote Lecture at the International Society for #Neuroimmunology in Chiba, Japan. We’re excited for several of our group members to be in Japan for this great meeting!
Amazing location (Maritime Museum of Barcelona), wonderful atmosphere, great people! Our group enjoyed getting to relax and interact with others from the #MultipleSclerosis research community at the #ECTRIMS2025 Party. 🥳
September 26, 2025 at 10:37 AM
Amazing location (Maritime Museum of Barcelona), wonderful atmosphere, great people! Our group enjoyed getting to relax and interact with others from the #MultipleSclerosis research community at the #ECTRIMS2025 Party. 🥳
Highlights from day 2 at #ECTRIMS2025 📸
Muriel, Maria and @katrinpape.bsky.social enjoying the chance to present their work. #iWiMS
Muriel, Maria and @katrinpape.bsky.social enjoying the chance to present their work. #iWiMS
September 25, 2025 at 8:07 PM
Highlights from day 2 at #ECTRIMS2025 📸
Muriel, Maria and @katrinpape.bsky.social enjoying the chance to present their work. #iWiMS
Muriel, Maria and @katrinpape.bsky.social enjoying the chance to present their work. #iWiMS
Thank you #ECTRIMS for giving clinician scientists like Muriel Schraad the opportunity to present their work to such a diverse and impactful community.
September 25, 2025 at 1:46 PM
Thank you #ECTRIMS for giving clinician scientists like Muriel Schraad the opportunity to present their work to such a diverse and impactful community.
We're excited for another great day at #ECTRIMS2025!
In the Free Communications 6 session (11:15-12:30 Lecture Hall 117), Muriel Schraad will present her talk entitled "Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in #MultipleSclerosis. More👇
In the Free Communications 6 session (11:15-12:30 Lecture Hall 117), Muriel Schraad will present her talk entitled "Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in #MultipleSclerosis. More👇
September 25, 2025 at 8:09 AM
We're excited for another great day at #ECTRIMS2025!
In the Free Communications 6 session (11:15-12:30 Lecture Hall 117), Muriel Schraad will present her talk entitled "Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in #MultipleSclerosis. More👇
In the Free Communications 6 session (11:15-12:30 Lecture Hall 117), Muriel Schraad will present her talk entitled "Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in #MultipleSclerosis. More👇
A few snapshots from Day 1 of #ECTRIMS2025!
September 24, 2025 at 5:30 PM
A few snapshots from Day 1 of #ECTRIMS2025!
We‘re looking forward to lots of interesting presentations and opportunities to (re)connect with others working in the #MS field at #ECTRIMS2025! Come find us at our posters or talks outlined below! 👇
September 24, 2025 at 6:24 AM
We‘re looking forward to lots of interesting presentations and opportunities to (re)connect with others working in the #MS field at #ECTRIMS2025! Come find us at our posters or talks outlined below! 👇
Reposted by Neurology Mainz
Excited to see our paper on the CD5 signalling pathway in Th17 cells and its role in #MultipleSclerosis out in @brain1878.bsky.social today. Thanks to everyone involved in this great team work! @neurologymainz.bsky.social @toszkabohn.bsky.social #ImmunoSky
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis
Pape et al. link the CD5-CK2-STAT3 signalling pathway to both inflammation and effector function in multiple sclerosis, using a multi-modal approach that c
academic.oup.com
August 26, 2025 at 5:43 PM
Excited to see our paper on the CD5 signalling pathway in Th17 cells and its role in #MultipleSclerosis out in @brain1878.bsky.social today. Thanks to everyone involved in this great team work! @neurologymainz.bsky.social @toszkabohn.bsky.social #ImmunoSky
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Out now in #SciTranslMed! We show non-canonical activity of AMPA receptor signaling in T cells. Oral selective noncompetitive AMPA receptor blockade ameliorates neuroinflammation by preventing T cell egress from lymph nodes and therefore may be repurposed to treat inflammatory conditions such as MS.
AMPAR inhibition lowers S1P in human blood and improves murine autoimmune neuroinflammation by blocking T cell egress from lymph nodes
A clinically available AMPAR antagonist inhibits T cell egress from lymph nodes and shows therapeutic effects in mouse models of multiple sclerosis.
doi.org
June 12, 2025 at 6:05 AM
Out now in #SciTranslMed! We show non-canonical activity of AMPA receptor signaling in T cells. Oral selective noncompetitive AMPA receptor blockade ameliorates neuroinflammation by preventing T cell egress from lymph nodes and therefore may be repurposed to treat inflammatory conditions such as MS.
Thank you to everyone who helped make the first European meeting of our Neuroimmune GRC a success! It was an amazing week of interesting science, lively discussions, and lovely evenings enjoying the Italian atmosphere. We look forward to our next meeting in 2027!
May 19, 2025 at 8:01 AM
Thank you to everyone who helped make the first European meeting of our Neuroimmune GRC a success! It was an amazing week of interesting science, lively discussions, and lovely evenings enjoying the Italian atmosphere. We look forward to our next meeting in 2027!
In our new paper, we show that multimodal biomarkers, i.e. different major surrogates for pathology derived from MRI, OCT and blood, inform about different parts of MS disease pathology leading to clinical progression.
Frontiers | Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis
www.frontiersin.org
February 7, 2025 at 4:28 PM
In our new paper, we show that multimodal biomarkers, i.e. different major surrogates for pathology derived from MRI, OCT and blood, inform about different parts of MS disease pathology leading to clinical progression.
Happy to join the Bluesky Community!
January 17, 2025 at 8:04 AM
Happy to join the Bluesky Community!