Ying Cao
@neuralgrndstate.bsky.social
Cancer is a systemic disease. Understanding a systemic disease needs systemic rules: Tumorigenesis is a process of progressive loss of original cell identity and gain of neural stemness, the general stemness that determines tumorigenicity and pluripotency.
Researchers who believe EMT is helpful for understanding cancer&other things should first clarify
ON WHAT BASIS EMT IS ESTABLISHED AS A CONCEPT OR RULE.
'Lack of basic rationale in EMT..’ cellandbioscience.biomedcentral.com/articles/10....
@nataging.nature.com
ON WHAT BASIS EMT IS ESTABLISHED AS A CONCEPT OR RULE.
'Lack of basic rationale in EMT..’ cellandbioscience.biomedcentral.com/articles/10....
@nataging.nature.com
November 7, 2025 at 7:17 AM
Researchers who believe EMT is helpful for understanding cancer&other things should first clarify
ON WHAT BASIS EMT IS ESTABLISHED AS A CONCEPT OR RULE.
'Lack of basic rationale in EMT..’ cellandbioscience.biomedcentral.com/articles/10....
@nataging.nature.com
ON WHAT BASIS EMT IS ESTABLISHED AS A CONCEPT OR RULE.
'Lack of basic rationale in EMT..’ cellandbioscience.biomedcentral.com/articles/10....
@nataging.nature.com
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
cellandbioscience.biomedcentral.com/articles/10....
November 2, 2025 at 7:17 AM
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
cellandbioscience.biomedcentral.com/articles/10....
Those who believe that EMT/MET/EndMT can help understand cancer and other stuffs should at least and at first figure out
WHAT THE HELL IS THE MESENCHYMAL STATE or ON WHAT BASIS EMT/MET/EndMT ARE ESTABLISHED AS CONCEPTS OR RULES.
journals.physiology.org/doi/abs/10.1...
WHAT THE HELL IS THE MESENCHYMAL STATE or ON WHAT BASIS EMT/MET/EndMT ARE ESTABLISHED AS CONCEPTS OR RULES.
journals.physiology.org/doi/abs/10.1...
COL8A1 Regulates Endothelial Phenotype in Inflammatory Endothelial-to-Mesenchymal Transition | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Society
Background: Endothelial-to-mesenchymal transition (EndMT) has been implicated in inflammatory vascular pathologies such as atherosclerosis. The non-fibrillar collagen type VIII functions as a pivotal ...
journals.physiology.org
November 2, 2025 at 7:16 AM
Those who believe that EMT/MET/EndMT can help understand cancer and other stuffs should at least and at first figure out
WHAT THE HELL IS THE MESENCHYMAL STATE or ON WHAT BASIS EMT/MET/EndMT ARE ESTABLISHED AS CONCEPTS OR RULES.
journals.physiology.org/doi/abs/10.1...
WHAT THE HELL IS THE MESENCHYMAL STATE or ON WHAT BASIS EMT/MET/EndMT ARE ESTABLISHED AS CONCEPTS OR RULES.
journals.physiology.org/doi/abs/10.1...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
preprints.org/manuscript/2...
November 2, 2025 at 7:12 AM
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
preprints.org/manuscript/2...
Beautiful mol. mechanisms👏
But evidence shows FIGNL1 is a cancer promoting factor.
As generalized before, most cancer promoting factors are embryonic neural factors, inclu. FIGNL1.
Therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness.
But evidence shows FIGNL1 is a cancer promoting factor.
As generalized before, most cancer promoting factors are embryonic neural factors, inclu. FIGNL1.
Therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness.
November 2, 2025 at 7:11 AM
Beautiful mol. mechanisms👏
But evidence shows FIGNL1 is a cancer promoting factor.
As generalized before, most cancer promoting factors are embryonic neural factors, inclu. FIGNL1.
Therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness.
But evidence shows FIGNL1 is a cancer promoting factor.
As generalized before, most cancer promoting factors are embryonic neural factors, inclu. FIGNL1.
Therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness.
Neural is fundamental.
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
November 1, 2025 at 3:55 AM
Neural is fundamental.
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
Those who believe that EMT is helpful for understanding cancer and other things should first figure out
what the hell is the so-called EMT?
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
what the hell is the so-called EMT?
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
November 1, 2025 at 3:51 AM
Those who believe that EMT is helpful for understanding cancer and other things should first figure out
what the hell is the so-called EMT?
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
what the hell is the so-called EMT?
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....
Some told me that TME should be more concentrated in developing cancer therapy because of inefficiency in targeting cancer cell itself.
But how much is cancer cell really understood?
'..promote epithelial-mesenchymal transition and stemness in breast cancer cells'
sciencedirect.com/science/arti...
But how much is cancer cell really understood?
'..promote epithelial-mesenchymal transition and stemness in breast cancer cells'
sciencedirect.com/science/arti...
November 1, 2025 at 3:43 AM
Some told me that TME should be more concentrated in developing cancer therapy because of inefficiency in targeting cancer cell itself.
But how much is cancer cell really understood?
'..promote epithelial-mesenchymal transition and stemness in breast cancer cells'
sciencedirect.com/science/arti...
But how much is cancer cell really understood?
'..promote epithelial-mesenchymal transition and stemness in breast cancer cells'
sciencedirect.com/science/arti...
Everything in the animal world is ultimately the result of neural stemness, including cancer and cancer research.🤭😏😇
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
October 29, 2025 at 6:04 AM
Everything in the animal world is ultimately the result of neural stemness, including cancer and cancer research.🤭😏😇
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
While I have no chance to publish my research in eye-catching journals and have no chance to present them at any conferences, I made two PPT files to summarize my view on cancer and epithelial-msenchymal transition.
The links:
pan.baidu.com/s/15QX8uI1Aj...
pan.baidu.com/s/1LFm2Q-gYh...
The links:
pan.baidu.com/s/15QX8uI1Aj...
pan.baidu.com/s/1LFm2Q-gYh...
October 27, 2025 at 12:09 PM
While I have no chance to publish my research in eye-catching journals and have no chance to present them at any conferences, I made two PPT files to summarize my view on cancer and epithelial-msenchymal transition.
The links:
pan.baidu.com/s/15QX8uI1Aj...
pan.baidu.com/s/1LFm2Q-gYh...
The links:
pan.baidu.com/s/15QX8uI1Aj...
pan.baidu.com/s/1LFm2Q-gYh...
It would be not a surprise if basic rules in cancer are understood.😆😋🧐
1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2.
2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity.
blog.google/technology/a...
1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2.
2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity.
blog.google/technology/a...
How a Gemma model helped discover a new potential cancer therapy pathway
We’re launching a new 27 billion parameter foundation model for single-cell analysis built on the Gemma family of open models.
blog.google
October 17, 2025 at 12:20 PM
It would be not a surprise if basic rules in cancer are understood.😆😋🧐
1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2.
2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity.
blog.google/technology/a...
1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2.
2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity.
blog.google/technology/a...
LEADING EDGE study of Epithelial-mesenchymal transition in latest @cp-cell.bsky.social
@nature.com
@natureportfolio.nature.com
@scinews.bsky.social
cell.com/cell/fulltex...
'Lack of basic rationale in epithelial-mesenchymal transition ..'
cellandbioscience.biomedcentral.com/articles/10....
@nature.com
@natureportfolio.nature.com
@scinews.bsky.social
cell.com/cell/fulltex...
'Lack of basic rationale in epithelial-mesenchymal transition ..'
cellandbioscience.biomedcentral.com/articles/10....
October 8, 2025 at 7:57 AM
LEADING EDGE study of Epithelial-mesenchymal transition in latest @cp-cell.bsky.social
@nature.com
@natureportfolio.nature.com
@scinews.bsky.social
cell.com/cell/fulltex...
'Lack of basic rationale in epithelial-mesenchymal transition ..'
cellandbioscience.biomedcentral.com/articles/10....
@nature.com
@natureportfolio.nature.com
@scinews.bsky.social
cell.com/cell/fulltex...
'Lack of basic rationale in epithelial-mesenchymal transition ..'
cellandbioscience.biomedcentral.com/articles/10....
In the latest issue of CELL!
Researchers reported the LEADING EDGE study of Epithelial-mesenchymal transition.
@cp-cell.bsky.social @nature.com @natureportfolio.nature.com @scinews.bsky.social
www.cell.com/cell/fulltex...
Researchers reported the LEADING EDGE study of Epithelial-mesenchymal transition.
@cp-cell.bsky.social @nature.com @natureportfolio.nature.com @scinews.bsky.social
www.cell.com/cell/fulltex...
Epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) is a conserved multi-step cellular program
that plays an essential role across a range of biological processes. This review covers
the roles and states of EMT i...
www.cell.com
October 8, 2025 at 7:25 AM
In the latest issue of CELL!
Researchers reported the LEADING EDGE study of Epithelial-mesenchymal transition.
@cp-cell.bsky.social @nature.com @natureportfolio.nature.com @scinews.bsky.social
www.cell.com/cell/fulltex...
Researchers reported the LEADING EDGE study of Epithelial-mesenchymal transition.
@cp-cell.bsky.social @nature.com @natureportfolio.nature.com @scinews.bsky.social
www.cell.com/cell/fulltex...
Neuroendocrine tumors surprisingly do not originate from neuroendocrine cells,
and there exists muscle cancer with non-muscle origin,
and osteosarcomas with extraskeletal origin.
Hard to understand?
'..Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
and there exists muscle cancer with non-muscle origin,
and osteosarcomas with extraskeletal origin.
Hard to understand?
'..Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
October 6, 2025 at 2:55 AM
Neuroendocrine tumors surprisingly do not originate from neuroendocrine cells,
and there exists muscle cancer with non-muscle origin,
and osteosarcomas with extraskeletal origin.
Hard to understand?
'..Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
and there exists muscle cancer with non-muscle origin,
and osteosarcomas with extraskeletal origin.
Hard to understand?
'..Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
Cancer is confusing:
Neuroendocrine tumors surprisingly do not originate from neuroendocrine cells,
and (some) muscle cancer originate from non-muscle cells.
Hard to understand?
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
Neuroendocrine tumors surprisingly do not originate from neuroendocrine cells,
and (some) muscle cancer originate from non-muscle cells.
Hard to understand?
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
October 5, 2025 at 12:14 PM
Cancer is confusing:
Neuroendocrine tumors surprisingly do not originate from neuroendocrine cells,
and (some) muscle cancer originate from non-muscle cells.
Hard to understand?
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
Neuroendocrine tumors surprisingly do not originate from neuroendocrine cells,
and (some) muscle cancer originate from non-muscle cells.
Hard to understand?
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
Cancer (tumorigenic) cells are characteristic of neural stem/embryonic neural cells, are capable of neuronal-like differentiation&making connections with host neural cells.
@cp-cancercell.bsky.social
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
@cp-cancercell.bsky.social
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
October 3, 2025 at 7:22 AM
Cancer (tumorigenic) cells are characteristic of neural stem/embryonic neural cells, are capable of neuronal-like differentiation&making connections with host neural cells.
@cp-cancercell.bsky.social
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
@cp-cancercell.bsky.social
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
Cancer (tumorigenic) cells are characteristic of neural stem/embryonic neural cells, are capable of neuronal-like differentiation&making connections with host neural cells.
@cp-cancercell.bsky.social
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
@cp-cancercell.bsky.social
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
October 3, 2025 at 7:18 AM
Cancer (tumorigenic) cells are characteristic of neural stem/embryonic neural cells, are capable of neuronal-like differentiation&making connections with host neural cells.
@cp-cancercell.bsky.social
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
@cp-cancercell.bsky.social
'..Understanding Neural Stemness as the Core Property of Cancer Cell'
preprints.org/manuscript/2...
Simply put, cancer cell can be induced to neuronal (&non-neural) differentiation, thereby suppressing cancer cell tumorigenicity.
@nature.com
‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
@nature.com
‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
September 30, 2025 at 11:36 AM
Simply put, cancer cell can be induced to neuronal (&non-neural) differentiation, thereby suppressing cancer cell tumorigenicity.
@nature.com
‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
@nature.com
‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
@natureportfolio.nature.com
What the hell the poorly defined EMT stuff can help to understand cancer?
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
www.nature.com/articles/s41...
What the hell the poorly defined EMT stuff can help to understand cancer?
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
www.nature.com/articles/s41...
Identification, functional insights and therapeutic targeting of EMT tumour states - Nature Reviews Cancer
In this Review, Dong and Blanpain outline our current understanding of the epithelial-to-mesenchymal transition in cancer, which we now know is not a simple binary switch but the existence of a series of different tumour states. The authors also discuss the implications of this knowledge for pharmacologically targeting epithelial-to-mesenchymal transition to overcome therapy resistance.
www.nature.com
September 26, 2025 at 1:24 PM
@natureportfolio.nature.com
What the hell the poorly defined EMT stuff can help to understand cancer?
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
www.nature.com/articles/s41...
What the hell the poorly defined EMT stuff can help to understand cancer?
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
www.nature.com/articles/s41...
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
"Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell"
www.preprints.org/manuscript/2...
cellandbioscience.biomedcentral.com/articles/10....
"Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell"
www.preprints.org/manuscript/2...
September 26, 2025 at 1:15 PM
'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
"Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell"
www.preprints.org/manuscript/2...
cellandbioscience.biomedcentral.com/articles/10....
"Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell"
www.preprints.org/manuscript/2...
What the hell the extremely poorly defined EMT stuff can help to understand cancer? @cp-devcell.bsky.social
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
www.cell.com/developmenta...
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
www.cell.com/developmenta...
Emerging insights into lineage plasticity in pancreatic cancer initiation, progression, and therapy resistance
Lineage plasticity underlies several pathogenic and aggressiveness-associated processes
in pancreatic ductal adenocarcinoma (PDAC). In this review, Zhang et al. explore how
normal and tumor cells in t...
www.cell.com
September 25, 2025 at 7:22 AM
What the hell the extremely poorly defined EMT stuff can help to understand cancer? @cp-devcell.bsky.social
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
www.cell.com/developmenta...
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
www.cell.com/developmenta...
What the hell the poorly defined EMT stuff can help to understand cancer?
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
September 25, 2025 at 6:11 AM
What the hell the poorly defined EMT stuff can help to understand cancer?
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
What the hell the extremely poorly defined EMT stuff can help to understand cancer? @drweb2.bsky.social
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
September 25, 2025 at 6:06 AM
What the hell the extremely poorly defined EMT stuff can help to understand cancer? @drweb2.bsky.social
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
What the hell the extremely poorly defined EMT stuff can help to understand cancer? @bigearthdata.bsky.social
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
September 25, 2025 at 6:01 AM
What the hell the extremely poorly defined EMT stuff can help to understand cancer? @bigearthdata.bsky.social
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
What the hell can the poorly defined EMT stuff be a little bit helpful for understanding cancer? @nature.com
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
September 25, 2025 at 5:56 AM
What the hell can the poorly defined EMT stuff be a little bit helpful for understanding cancer? @nature.com
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....
''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts"
cellandbioscience.biomedcentral.com/articles/10....