jefferson triozzi
nepherson.bsky.social
jefferson triozzi
@nepherson.bsky.social
nephrology
Fun fact, metformin and biguanides come from the purple lilac flower
February 23, 2025 at 4:32 AM
🤣
Well metformin was discovered first, so…
February 23, 2025 at 4:31 AM
Metformin associated lactic acidosis is real… but that warning really came from phenformin (one of the OG biguanides which was pulled from the market).
February 21, 2025 at 6:07 PM
Or if you’re CKD IV and you get really sick and develop lactic acidosis for other reasons, metformin is probably not helping matters…but should that keep us from prescribing. Risk vs Benefit varies!!!
February 21, 2025 at 6:05 PM
Nice! Thank you
December 16, 2024 at 10:47 AM
What p-value threshold do you use for PheWAS. Especially if performing multiple PheWASes in a single study?
December 13, 2024 at 10:00 PM
Link broken now.

What p-value threshold do you use for PheWAS?
December 13, 2024 at 9:59 PM
Maybe a better name than “CKM” is “MKC”

Metabolic➡️Kidney➡️Cardiovascular
December 13, 2024 at 9:37 PM
Um… diuretics?!
December 13, 2024 at 12:48 AM
Reposted by jefferson triozzi
In conclusion:
💥I don't use albumin/diuretic combinations because the literature doesn't support the practice
💥I think the overfill hypothesis predominates
💥An exception may be minimal change disease (particularly children) which is typically an abrupt presentation
November 17, 2024 at 2:56 AM
Thanks for posting this!
November 8, 2024 at 7:48 PM