Nelson Lau Lab
@nelson-lau-lab.bsky.social
Piwi and piRNA and pugs enthusiast. Tennis on occasions. http://laulab.bu.edu
Polarize? Or traumatize? Or both?
November 5, 2025 at 3:03 AM
Polarize? Or traumatize? Or both?
Truly heartbreaking💔 and alarmingly becoming more common for our lab members from overseas. I try hard to reassure my own group while acknowledging the non-scientific challenges to wanting to study here.
October 31, 2025 at 9:53 PM
Truly heartbreaking💔 and alarmingly becoming more common for our lab members from overseas. I try hard to reassure my own group while acknowledging the non-scientific challenges to wanting to study here.
For girl:
miRNA
Mili
For boy:
siRNA
Hiwi
miRNA
Mili
For boy:
siRNA
Hiwi
October 30, 2025 at 4:43 PM
For girl:
miRNA
Mili
For boy:
siRNA
Hiwi
miRNA
Mili
For boy:
siRNA
Hiwi
Is caviar good value or overpriced? Fishy-tasting? Lots of Seq, but what is the mechanism?
October 22, 2025 at 10:10 PM
Is caviar good value or overpriced? Fishy-tasting? Lots of Seq, but what is the mechanism?
That is quite unfortunate that if there are soooo many examples, those are not included in your manuscript. Wasn't that the point of your original Bluesky post asking the research community about dubious microRNAs? Maybe post an addendum on MirGeneDB that lists all these dubious candidates?
October 22, 2025 at 7:59 PM
That is quite unfortunate that if there are soooo many examples, those are not included in your manuscript. Wasn't that the point of your original Bluesky post asking the research community about dubious microRNAs? Maybe post an addendum on MirGeneDB that lists all these dubious candidates?
Thanks! Interesting perspective. But how come your perspective did not comment on the mir-548xx family? I thought in our messaging here you also felt mir-548xx was dubious and rejected as a TE? Why didn't your perspective comment on this, it would have been useful to have this in the literature.
October 22, 2025 at 7:19 PM
Thanks! Interesting perspective. But how come your perspective did not comment on the mir-548xx family? I thought in our messaging here you also felt mir-548xx was dubious and rejected as a TE? Why didn't your perspective comment on this, it would have been useful to have this in the literature.
PO's warned R01 renewal odds abysmal, better luck trying to convert R01 to R35 MIRA asap. After trying both approaches, competing renewal definitely DOA, zero empathy for pandemic impact, while MIRA still a crapshoot, reviewers wanted R01 despite MIRA instructions. And now shutdown! FML!
September 30, 2025 at 5:13 AM
PO's warned R01 renewal odds abysmal, better luck trying to convert R01 to R35 MIRA asap. After trying both approaches, competing renewal definitely DOA, zero empathy for pandemic impact, while MIRA still a crapshoot, reviewers wanted R01 despite MIRA instructions. And now shutdown! FML!
Thanks! Will send you an email after I'm done with my fall teaching!
September 18, 2025 at 5:45 PM
Thanks! Will send you an email after I'm done with my fall teaching!
Thanks! Is there an infectious clone of PCLV?
September 18, 2025 at 5:45 PM
Thanks! Is there an infectious clone of PCLV?
We study how the mosquito Piwi pathway molecularly interacts with arboviruses and bunyaviruses. But we don't yet know how to manipulate these viruses as infectious clones. Do you have tips on this?
September 17, 2025 at 9:59 PM
We study how the mosquito Piwi pathway molecularly interacts with arboviruses and bunyaviruses. But we don't yet know how to manipulate these viruses as infectious clones. Do you have tips on this?
And the piRNA citations on your page mirgenedb.org/information only cite Tuschl, Hannon, Lin lab papers, but left out mine published at same time: pubmed.ncbi.nlm.nih.gov/16778019/ . I would appreciate if you could add our paper: www.science.org/doi/10.1126/...
Characterization of the piRNA Complex from Rat Testes
Small noncoding RNAs regulate processes essential for cell growth and development, including mRNA degradation, translational repression, and transcriptional gene silencing (TGS). During a search for c...
www.science.org
August 28, 2025 at 3:32 PM
And the piRNA citations on your page mirgenedb.org/information only cite Tuschl, Hannon, Lin lab papers, but left out mine published at same time: pubmed.ncbi.nlm.nih.gov/16778019/ . I would appreciate if you could add our paper: www.science.org/doi/10.1126/...
I finally took a good look at mirgenedb.org/information. Very useful! I will do more to compare it against miRBase, since they did not reject the bad miR-548. Have you tried to get more consistency between miRBase and mirgenedb?
Info
mirgenedb.org
August 28, 2025 at 3:27 PM
I finally took a good look at mirgenedb.org/information. Very useful! I will do more to compare it against miRBase, since they did not reject the bad miR-548. Have you tried to get more consistency between miRBase and mirgenedb?
What is your impression of the hsa-mir-548xxx family of microRNAs? MITEs foldback masquerading as a "miRNA"? We've seen an instance where total mRNA across the mir-548-y locus go way up, but zero increase in mature mir-548-y or any other mir-548-xxx member.
August 27, 2025 at 10:45 PM
What is your impression of the hsa-mir-548xxx family of microRNAs? MITEs foldback masquerading as a "miRNA"? We've seen an instance where total mRNA across the mir-548-y locus go way up, but zero increase in mature mir-548-y or any other mir-548-xxx member.
WHY? Just why? Those cards are disturbing on so many levels, and lacking representation of plant biologists like how Nobels passed over Baulcombe and Benning. It was Benning who first coined the name Argonaute for these genes.
August 27, 2025 at 6:21 PM
WHY? Just why? Those cards are disturbing on so many levels, and lacking representation of plant biologists like how Nobels passed over Baulcombe and Benning. It was Benning who first coined the name Argonaute for these genes.
BSMART, NASTY, or CLASSY? A skeet game I play with @lucksmith.bsky.social
August 6, 2025 at 4:16 AM
BSMART, NASTY, or CLASSY? A skeet game I play with @lucksmith.bsky.social
Is this halt of just new not yet NOGA's, or does the halt also apply to all Non-Competing ongoing grants in FY25/FY26?
July 30, 2025 at 3:41 AM
Is this halt of just new not yet NOGA's, or does the halt also apply to all Non-Competing ongoing grants in FY25/FY26?
Take care and hope all that caloric restriction helps you live longer!
July 30, 2025 at 3:12 AM
Take care and hope all that caloric restriction helps you live longer!
Case in point, HHMI? No offense to @harmitmalik.bsky.social, you are one of the most vocal advocates here! But what is your insider insight into your HHMI colleagues and the HHMI brass? Can they throw out just some lifejackets to those barely treading water?
July 29, 2025 at 4:23 PM
Case in point, HHMI? No offense to @harmitmalik.bsky.social, you are one of the most vocal advocates here! But what is your insider insight into your HHMI colleagues and the HHMI brass? Can they throw out just some lifejackets to those barely treading water?