Nelesh Govender
@neleshg.bsky.social
I study fungal and bacterial diseases. Prof at Wits. @nihr Global Health Research Prof. Hon Prof at MRC-CMM @uniofexeter, City-St George's and UCT. On sabbatical from NICD. MD, micro, epi 🌈
🎉to Charlotte Rabault - she published this after a 6-month fellowship in Joburg
In patients aged >90 days, prior antifungal use was associated with non-susceptible Candida bloodstream infection (OR 2.02). In young infants, hospital transmission was more influential.
wwwnc.cdc.gov/eid/article/...
In patients aged >90 days, prior antifungal use was associated with non-susceptible Candida bloodstream infection (OR 2.02). In young infants, hospital transmission was more influential.
wwwnc.cdc.gov/eid/article/...
September 27, 2025 at 10:29 AM
🎉to Charlotte Rabault - she published this after a 6-month fellowship in Joburg
In patients aged >90 days, prior antifungal use was associated with non-susceptible Candida bloodstream infection (OR 2.02). In young infants, hospital transmission was more influential.
wwwnc.cdc.gov/eid/article/...
In patients aged >90 days, prior antifungal use was associated with non-susceptible Candida bloodstream infection (OR 2.02). In young infants, hospital transmission was more influential.
wwwnc.cdc.gov/eid/article/...
Results from our CAST-NET cohort study published. Excellent national coverage of cryptococcal antigen screening in SA but real challenges to act on CrAg+ results to exclude meningitis and dispense pre-emptive antifungals
journals.lww.com/jaids/abstra...
journals.lww.com/jaids/abstra...
July 17, 2025 at 11:46 AM
Results from our CAST-NET cohort study published. Excellent national coverage of cryptococcal antigen screening in SA but real challenges to act on CrAg+ results to exclude meningitis and dispense pre-emptive antifungals
journals.lww.com/jaids/abstra...
journals.lww.com/jaids/abstra...
Jayne Ellis presenting data from our cohort with CD4 <100 undergoing CrAg screening in SA at #IAS2025 (poster 2803)
59% (86/146) had CMV viraemia - strongly & independently associated with ⬆️mortality, more than quadrupling odds of death at 6-months (adjusted OR 4.02, 95%CI 1.27-12.7)
59% (86/146) had CMV viraemia - strongly & independently associated with ⬆️mortality, more than quadrupling odds of death at 6-months (adjusted OR 4.02, 95%CI 1.27-12.7)
July 14, 2025 at 8:36 AM
Jayne Ellis presenting data from our cohort with CD4 <100 undergoing CrAg screening in SA at #IAS2025 (poster 2803)
59% (86/146) had CMV viraemia - strongly & independently associated with ⬆️mortality, more than quadrupling odds of death at 6-months (adjusted OR 4.02, 95%CI 1.27-12.7)
59% (86/146) had CMV viraemia - strongly & independently associated with ⬆️mortality, more than quadrupling odds of death at 6-months (adjusted OR 4.02, 95%CI 1.27-12.7)
Great updates and learning at the histoplasmosis working group meeting at the tail end of ISHAM triennial conference
And new targets will be set...
And new targets will be set...
May 25, 2025 at 3:36 PM
Great updates and learning at the histoplasmosis working group meeting at the tail end of ISHAM triennial conference
And new targets will be set...
And new targets will be set...
Congratulations Lottie
May 20, 2025 at 4:57 PM
Congratulations Lottie
Nice cover of Emerging Infectious Diseases Journal, highlighting the still-mysterious fungal kingdom, a small % of which causes deadly human infections
"Nature alone is antique, and the oldest art a mushroom" -https://wwwnc.cdc.gov/eid/article/31/5/ac-3105_article
"Nature alone is antique, and the oldest art a mushroom" -https://wwwnc.cdc.gov/eid/article/31/5/ac-3105_article
April 24, 2025 at 2:03 PM
Nice cover of Emerging Infectious Diseases Journal, highlighting the still-mysterious fungal kingdom, a small % of which causes deadly human infections
"Nature alone is antique, and the oldest art a mushroom" -https://wwwnc.cdc.gov/eid/article/31/5/ac-3105_article
"Nature alone is antique, and the oldest art a mushroom" -https://wwwnc.cdc.gov/eid/article/31/5/ac-3105_article
Our suggested interventions for prevention and treatment of AHD-related sepsis
April 24, 2025 at 12:09 PM
Our suggested interventions for prevention and treatment of AHD-related sepsis
Proceedings of the 2024 AIDS-related mycoses meeting in Cape Town, SA
We discuss advances, challenges, and future directions - full text link below
authors.elsevier.com/c/1kNnb,L~yC...
We discuss advances, challenges, and future directions - full text link below
authors.elsevier.com/c/1kNnb,L~yC...
January 6, 2025 at 8:38 AM
Proceedings of the 2024 AIDS-related mycoses meeting in Cape Town, SA
We discuss advances, challenges, and future directions - full text link below
authors.elsevier.com/c/1kNnb,L~yC...
We discuss advances, challenges, and future directions - full text link below
authors.elsevier.com/c/1kNnb,L~yC...
And in a phase 2 trial of LAmB, 63/105 (64%) had +RTqPCR at diagnosis. ↗️➡️whole nucleic acid load in blood (measured by RTqPCR) during antifungal treatment associated with death at various timepoints
www.clinicalmicrobiologyandinfection.com/article/S119...
www.clinicalmicrobiologyandinfection.com/article/S119...
December 27, 2024 at 10:41 AM
And in a phase 2 trial of LAmB, 63/105 (64%) had +RTqPCR at diagnosis. ↗️➡️whole nucleic acid load in blood (measured by RTqPCR) during antifungal treatment associated with death at various timepoints
www.clinicalmicrobiologyandinfection.com/article/S119...
www.clinicalmicrobiologyandinfection.com/article/S119...
We still don't know if TMP-SMX is the best treatment for HIV-associated PCP...new trials needed
14 trials, 1983-1996, 96% male participants, high-income countries, 9/14 w/ <100 participants, no other regimen superior, comparators less toxic
www.clinicalmicrobiologyandinfection.com/article/S119...
14 trials, 1983-1996, 96% male participants, high-income countries, 9/14 w/ <100 participants, no other regimen superior, comparators less toxic
www.clinicalmicrobiologyandinfection.com/article/S119...
December 27, 2024 at 10:27 AM
We still don't know if TMP-SMX is the best treatment for HIV-associated PCP...new trials needed
14 trials, 1983-1996, 96% male participants, high-income countries, 9/14 w/ <100 participants, no other regimen superior, comparators less toxic
www.clinicalmicrobiologyandinfection.com/article/S119...
14 trials, 1983-1996, 96% male participants, high-income countries, 9/14 w/ <100 participants, no other regimen superior, comparators less toxic
www.clinicalmicrobiologyandinfection.com/article/S119...
Among 27 people w/ HIV-associated histoplasmosis (treated with amphotericin B), median Histo antigenuria levels measured by IMMY Clarus ⬇️from 35 ng/ml (26 EIA units) at diagnosis to 0.8 ng/ml (0.5 EIA units) at 6m.
academic.oup.com/mmy/advance-...
academic.oup.com/mmy/advance-...
December 27, 2024 at 10:14 AM
Among 27 people w/ HIV-associated histoplasmosis (treated with amphotericin B), median Histo antigenuria levels measured by IMMY Clarus ⬇️from 35 ng/ml (26 EIA units) at diagnosis to 0.8 ng/ml (0.5 EIA units) at 6m.
academic.oup.com/mmy/advance-...
academic.oup.com/mmy/advance-...
"On the basis of current trends [38% of all dermatophytes at UK NMRL in 2024], we predict T. indotineae will rapidly become the predominant cause of tinea corporis in the United Kingdom."
December 19, 2024 at 10:19 AM
"On the basis of current trends [38% of all dermatophytes at UK NMRL in 2024], we predict T. indotineae will rapidly become the predominant cause of tinea corporis in the United Kingdom."
Fun photo of the NICD CHARM and Wits Mycology teams marking the start of World Antimicrobial Awareness Week today in blue
(Disclaimer: gloves are not a substitute for hand hygiene!)
(Disclaimer: gloves are not a substitute for hand hygiene!)
November 18, 2024 at 12:34 PM
Fun photo of the NICD CHARM and Wits Mycology teams marking the start of World Antimicrobial Awareness Week today in blue
(Disclaimer: gloves are not a substitute for hand hygiene!)
(Disclaimer: gloves are not a substitute for hand hygiene!)