Nejc Haberman
@nejchaberman.bsky.social
Imperial College Research Fellow at Department of Brain Sciences
Computational biology | RNA Biology | RNA-binding proteins | Splicing | Aging | 3'UTR processing | lncRNA
https://profiles.imperial.ac.uk/n.haberman
Computational biology | RNA Biology | RNA-binding proteins | Splicing | Aging | 3'UTR processing | lncRNA
https://profiles.imperial.ac.uk/n.haberman
What an incredible end to the Eukaryotic RNA Turnover meeting in Brighton! Fantastic talks, inspiring speakers, and amazing to meet so many new RNA enthusiasts. Thanks @biochemsoc.bsky.social for a great conference! #BiochemEvent
August 29, 2025 at 1:41 PM
What an incredible end to the Eukaryotic RNA Turnover meeting in Brighton! Fantastic talks, inspiring speakers, and amazing to meet so many new RNA enthusiasts. Thanks @biochemsoc.bsky.social for a great conference! #BiochemEvent
Fantastic day at the Eukaryotic RNA Turnover meeting!
We wrapped up insightful sessions on:
- RNA therapeutics & RNA modification
- RNA molecular machines & RNA-binding proteins
- RNA localization & turnover
Thanks to all speakers! @biochemsoc.bsky.social #BiochemEvent
We wrapped up insightful sessions on:
- RNA therapeutics & RNA modification
- RNA molecular machines & RNA-binding proteins
- RNA localization & turnover
Thanks to all speakers! @biochemsoc.bsky.social #BiochemEvent
August 28, 2025 at 3:16 PM
Fantastic day at the Eukaryotic RNA Turnover meeting!
We wrapped up insightful sessions on:
- RNA therapeutics & RNA modification
- RNA molecular machines & RNA-binding proteins
- RNA localization & turnover
Thanks to all speakers! @biochemsoc.bsky.social #BiochemEvent
We wrapped up insightful sessions on:
- RNA therapeutics & RNA modification
- RNA molecular machines & RNA-binding proteins
- RNA localization & turnover
Thanks to all speakers! @biochemsoc.bsky.social #BiochemEvent
What a beautiful morning by the Brighton sea to kick off another exciting session at the Eukaryotic RNA Turnover meeting! ☀️🌊 @biochemsoc.bsky.social #BiochemEvent
August 28, 2025 at 8:47 AM
What a beautiful morning by the Brighton sea to kick off another exciting session at the Eukaryotic RNA Turnover meeting! ☀️🌊 @biochemsoc.bsky.social #BiochemEvent
November 22, 2024 at 4:19 PM
9/10
In summary, we demonstrate that that capped 3′UTR-derived RNAs arise from structured G-motif-rich regions bound by AGO2 and UPF1, and they localise separately from their parental mRNAs.
In summary, we demonstrate that that capped 3′UTR-derived RNAs arise from structured G-motif-rich regions bound by AGO2 and UPF1, and they localise separately from their parental mRNAs.
November 15, 2024 at 5:14 PM
9/10
In summary, we demonstrate that that capped 3′UTR-derived RNAs arise from structured G-motif-rich regions bound by AGO2 and UPF1, and they localise separately from their parental mRNAs.
In summary, we demonstrate that that capped 3′UTR-derived RNAs arise from structured G-motif-rich regions bound by AGO2 and UPF1, and they localise separately from their parental mRNAs.
8/10
Using high-resolution imaging, we validated that 3′UTR-derived RNAs localise differently from their parental mRNAs within the cell, hinting at potential independent functions.
Using high-resolution imaging, we validated that 3′UTR-derived RNAs localise differently from their parental mRNAs within the cell, hinting at potential independent functions.
November 15, 2024 at 5:12 PM
8/10
Using high-resolution imaging, we validated that 3′UTR-derived RNAs localise differently from their parental mRNAs within the cell, hinting at potential independent functions.
Using high-resolution imaging, we validated that 3′UTR-derived RNAs localise differently from their parental mRNAs within the cell, hinting at potential independent functions.
7/10
We also found that cytoplasmic capping can occur subsequent to AGO2/siRNA-mediated cleavage, by analysing FANTOM5 CAGE from siRNA-treated samples. Our findings demonstrate that capping can readily follow cytoplasmic cleavage, and is not exclusive to transcriptional initiation.
We also found that cytoplasmic capping can occur subsequent to AGO2/siRNA-mediated cleavage, by analysing FANTOM5 CAGE from siRNA-treated samples. Our findings demonstrate that capping can readily follow cytoplasmic cleavage, and is not exclusive to transcriptional initiation.
November 15, 2024 at 5:11 PM
7/10
We also found that cytoplasmic capping can occur subsequent to AGO2/siRNA-mediated cleavage, by analysing FANTOM5 CAGE from siRNA-treated samples. Our findings demonstrate that capping can readily follow cytoplasmic cleavage, and is not exclusive to transcriptional initiation.
We also found that cytoplasmic capping can occur subsequent to AGO2/siRNA-mediated cleavage, by analysing FANTOM5 CAGE from siRNA-treated samples. Our findings demonstrate that capping can readily follow cytoplasmic cleavage, and is not exclusive to transcriptional initiation.
6/10
Our analysis shows that AGO2 binds upstream of 3′UTR-derived RNA start sites—independent of miRNA binding. Interestingly, G4 motifs influence the binding positions of both AGO2 and UPF1, shaping the capping sites.
Our analysis shows that AGO2 binds upstream of 3′UTR-derived RNA start sites—independent of miRNA binding. Interestingly, G4 motifs influence the binding positions of both AGO2 and UPF1, shaping the capping sites.
November 15, 2024 at 5:10 PM
6/10
Our analysis shows that AGO2 binds upstream of 3′UTR-derived RNA start sites—independent of miRNA binding. Interestingly, G4 motifs influence the binding positions of both AGO2 and UPF1, shaping the capping sites.
Our analysis shows that AGO2 binds upstream of 3′UTR-derived RNA start sites—independent of miRNA binding. Interestingly, G4 motifs influence the binding positions of both AGO2 and UPF1, shaping the capping sites.
5/10
By integrating AGO2-eiCLIP, eCLIP, and CAGE-seq, we found their origins linked to RNA-binding proteins, specifically AGO2 and UPF1. These sites are often rich in G-motifs capable of forming G-Quadruplexes.
By integrating AGO2-eiCLIP, eCLIP, and CAGE-seq, we found their origins linked to RNA-binding proteins, specifically AGO2 and UPF1. These sites are often rich in G-motifs capable of forming G-Quadruplexes.
November 15, 2024 at 5:09 PM
5/10
By integrating AGO2-eiCLIP, eCLIP, and CAGE-seq, we found their origins linked to RNA-binding proteins, specifically AGO2 and UPF1. These sites are often rich in G-motifs capable of forming G-Quadruplexes.
By integrating AGO2-eiCLIP, eCLIP, and CAGE-seq, we found their origins linked to RNA-binding proteins, specifically AGO2 and UPF1. These sites are often rich in G-motifs capable of forming G-Quadruplexes.
2/10
CAGE profiling often reveals signals (~10-15%) in 3′UTRs — regions far from usual transcription start sites (TSS). This phenomenon is reproducible but poorly understood.
CAGE profiling often reveals signals (~10-15%) in 3′UTRs — regions far from usual transcription start sites (TSS). This phenomenon is reproducible but poorly understood.
November 15, 2024 at 5:04 PM
2/10
CAGE profiling often reveals signals (~10-15%) in 3′UTRs — regions far from usual transcription start sites (TSS). This phenomenon is reproducible but poorly understood.
CAGE profiling often reveals signals (~10-15%) in 3′UTRs — regions far from usual transcription start sites (TSS). This phenomenon is reproducible but poorly understood.