Ralph Patrick is looking for dosage-sensitive transcription factors that may impact ageing #ASSCR2025 doi.org/10.1016/j.cm...

Really intriguing model of AP-1 driven aging.

@anshulkundaje.bsky.social @suragnair.bsky.social - thinking of your AP1-related results in the ChromBPNet paper here...

🙏 to Manuel Serrano for writing a preview for our study @ Cell Metabolism. A pattern emerges in chromatin aging: AP-1 steals the show dlvr.it/TBvzgR

Thanks to Longevity Technology for writing an article about our recent study:
"Master controller of aging and development uncovered.
New insights into transcription factors and chromatin remodeling reveal potential for improving age-related health outcomes. #innovation #aging "
t.co/a8Mxgowkbe

Thanks to EpiGenie for an article about our study: "Christian Nefzger's lab reveals how chromatin remodeling driven by the AP-1 pioneer transcription factor supports cell maturation. Beware o' the mechanism pirated during #aging to induce the appearance of age-related phenotypes!" bit.ly/3zOqBux

Our recent study in Cell Metabolism provides compelling evidence that chromatin accessibility and transcription factor network remodeling in aging reflect the predictable degrading effects of a mechanism initially driving organismal maturation.
Link: doi.org/10.1016/j.cmet.2024.06.006
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