Baker Lab @ Notre Dame
@nd-bakerlab.bsky.social
Structural and molecular immunology and protein biophysics at the University of Notre Dame. T cell receptors, MHC proteins, specificity, and cross-reactivity. Plus drums, odd time signatures, Iron Maiden, and much Rush. Opinions mine alone.
bmblab.nd.edu
bmblab.nd.edu
Lecturing on biomolecular equilibria this semester. This is in the classroom. Turns out it 100% lives up to the hype. Amazing stuff.
September 16, 2025 at 4:08 PM
Lecturing on biomolecular equilibria this semester. This is in the classroom. Turns out it 100% lives up to the hype. Amazing stuff.
A big chunk of the lab works on TCR cross-reactivity - the subgroup is called TCR-X. They made an image for their T shirts... Well played, TCR-X.
#immunosky
#immunosky
September 1, 2025 at 7:51 PM
A big chunk of the lab works on TCR cross-reactivity - the subgroup is called TCR-X. They made an image for their T shirts... Well played, TCR-X.
#immunosky
#immunosky
Here's how I think about it: via traditional short MD, if you're in a well separated by high barriers, it's almost always going to be like a paint by numbers picture where you get really really good at coloring in the cute puppy's ear. Maybe you get to learn it could be attached to a head.
August 21, 2025 at 5:24 PM
Here's how I think about it: via traditional short MD, if you're in a well separated by high barriers, it's almost always going to be like a paint by numbers picture where you get really really good at coloring in the cute puppy's ear. Maybe you get to learn it could be attached to a head.
Congratulations to the newly minted structural immunologist Dr. George Gray! George made killer progress quantifying TCR cross-reactivity and built a foundation we'll build on for years. The last of our COVID babies - we will miss him as he goes off to train the next generation! #immunosky
July 11, 2025 at 6:05 PM
Congratulations to the newly minted structural immunologist Dr. George Gray! George made killer progress quantifying TCR cross-reactivity and built a foundation we'll build on for years. The last of our COVID babies - we will miss him as he goes off to train the next generation! #immunosky
Super postdoc @chadbrambley.bsky.social killing it at the AI/HI Immunoinformatics workshop, telling us about finding molecular mimics of antigenic epitopes. Thanks to @epivax.bsky.social for the invitation and opportunity!
June 6, 2025 at 3:48 PM
Super postdoc @chadbrambley.bsky.social killing it at the AI/HI Immunoinformatics workshop, telling us about finding molecular mimics of antigenic epitopes. Thanks to @epivax.bsky.social for the invitation and opportunity!
Congratulations to the newly minted PhD, Dr. Sarah Catherine Baker Hawthorne! A cell biologist not a structural biologist, and not one of my students but still one of mine :) Super proud dad today. Next step California Science & Technology Policy. 💪🧪💪
June 4, 2025 at 11:59 AM
Congratulations to the newly minted PhD, Dr. Sarah Catherine Baker Hawthorne! A cell biologist not a structural biologist, and not one of my students but still one of mine :) Super proud dad today. Next step California Science & Technology Policy. 💪🧪💪
#Limelight in the elevator!! Up and down 2 times. #Rush Whoohoo! Elevator music is good in this otherwise crappy timeline.
June 2, 2025 at 5:23 PM
#Limelight in the elevator!! Up and down 2 times. #Rush Whoohoo! Elevator music is good in this otherwise crappy timeline.
Anyone care to place bets on when this changes?
May 30, 2025 at 8:44 PM
Anyone care to place bets on when this changes?
Another week, another NIH Guide with no new funding opportunities. Lost track of the number of weeks now - let's just call it n+1.
May 23, 2025 at 6:36 PM
Another week, another NIH Guide with no new funding opportunities. Lost track of the number of weeks now - let's just call it n+1.
I had to look. The comments on Amazon. Insane. "I really liked the tips it gives for including peptides in my daily routine." Then there's the pic below. I bet the follow up book is "The Power of G Coupled Protein Receptors" - just a quick search and replace away. Maybe go for the 10 volume set.
May 5, 2025 at 12:38 AM
I had to look. The comments on Amazon. Insane. "I really liked the tips it gives for including peptides in my daily routine." Then there's the pic below. I bet the follow up book is "The Power of G Coupled Protein Receptors" - just a quick search and replace away. Maybe go for the 10 volume set.
Best poster at AAI 😀 No, I'm not biased. Rock star structural immunologist and PhD student Bassant Eldaly telling her KRAS public neoantigen story. No down time, she talked two hours straight. Power to the next generation!!!
#immunosky #AAI
#immunosky #AAI
May 4, 2025 at 11:09 PM
Best poster at AAI 😀 No, I'm not biased. Rock star structural immunologist and PhD student Bassant Eldaly telling her KRAS public neoantigen story. No down time, she talked two hours straight. Power to the next generation!!!
#immunosky #AAI
#immunosky #AAI
Because it's Friday.
April 25, 2025 at 10:01 PM
Because it's Friday.
At least the second week in a row of no new funding opportunities (and a reminder of a cancellation). Not ominous, these are not the droids you're looking for.
April 18, 2025 at 7:11 PM
At least the second week in a row of no new funding opportunities (and a reminder of a cancellation). Not ominous, these are not the droids you're looking for.
Amen. I only do what I do because of Cosmos. I'll never forget the early 80s computer animation of DNA replication, followed by 10 year old me asking my mother how the enzyme knew what to do...
April 16, 2025 at 2:38 AM
Amen. I only do what I do because of Cosmos. I'll never forget the early 80s computer animation of DNA replication, followed by 10 year old me asking my mother how the enzyme knew what to do...
They're everywhere! Here's a particularly vicious one. Watch the fangs.
April 13, 2025 at 7:50 PM
They're everywhere! Here's a particularly vicious one. Watch the fangs.
Congratulations to the newly minted professional structural immunologist, Dr. Tatiana Rosales on passing her PhD defense!! Here's to Dr. Rosales and her cast of mighty morphin peptides!!
April 1, 2025 at 4:18 PM
Congratulations to the newly minted professional structural immunologist, Dr. Tatiana Rosales on passing her PhD defense!! Here's to Dr. Rosales and her cast of mighty morphin peptides!!
Just superstar @chadbrambley.bsky.social doing some computational immunology this past week. Double checking the numbers the old fashioned way.
March 29, 2025 at 2:03 AM
Just superstar @chadbrambley.bsky.social doing some computational immunology this past week. Double checking the numbers the old fashioned way.
Proud of the team, braving the cold to #standupforscience!
March 8, 2025 at 4:25 AM
Proud of the team, braving the cold to #standupforscience!
March 7, 2025 at 6:24 PM
Up to 19 listeners. Only one of them is me :) Album cover seems relevant to today...
March 3, 2025 at 6:39 PM
Up to 19 listeners. Only one of them is me :) Album cover seems relevant to today...
I am so excited. Small victories - find joy where you can. Preliminary data for the grant. @chadbrambley.bsky.social is a genius. Big errors because these are log scales, but still.
February 5, 2025 at 6:02 PM
I am so excited. Small victories - find joy where you can. Preliminary data for the grant. @chadbrambley.bsky.social is a genius. Big errors because these are log scales, but still.
In other news, this is really cool, trust me. Will almost certainly fall apart with more replicates, but we don't have those so yay, find joy where you can.
February 4, 2025 at 6:37 PM
In other news, this is really cool, trust me. Will almost certainly fall apart with more replicates, but we don't have those so yay, find joy where you can.