Nick Constantino
@ncons95.bsky.social
Neuroscience PhD candidate at the University of Kentucky | Boston University ‘18 | Sleep, metabolism and Alzheimer’s disease | Views are my own | https://www.macauleylab.com
Pinned
Nick Constantino
@ncons95.bsky.social
· Feb 18
Our latest in PNAS! 🎉
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate
fluctuations are a biomarker of sleep/wake transitions, where in...
www.pnas.org
Super excited to have my first 1st author paper out today! Thanks to all of our collaborators and my mentor @macauleylab.bsky.social !
Reposted by Nick Constantino
🔥New preprint from the lab! Led by @rileyirmen.bsky.social
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
Alzheimer's disease (AD) is not only characterized by amyloid-beta (Aβ) and tau pathology, but also by early and progressive disruptions in metabolism. Neuronal excitability is tightly coupled with me...
biorxiv.org
July 31, 2025 at 3:49 PM
🔥New preprint from the lab! Led by @rileyirmen.bsky.social
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
Reposted by Nick Constantino
A great write up on our recent work in PNAS attempting to understand metabolic drivers of sleep, led by @ncons95.bsky.social !
uknow.uky.edu/research/fue...
uknow.uky.edu/research/fue...
Fueling sleep: UK researchers show key metabolic link to restful nights
Scientists have long recognized the brain’s need for energy, but groundbreaking research from the University of Kentucky’s Sanders-Brown Center on Aging has now illuminated how the brain’s energy uti...
uknow.uky.edu
March 27, 2025 at 2:02 PM
A great write up on our recent work in PNAS attempting to understand metabolic drivers of sleep, led by @ncons95.bsky.social !
uknow.uky.edu/research/fue...
uknow.uky.edu/research/fue...
Reposted by Nick Constantino
Macauley Lab needed a win today!
Thank you to UK Women’s Basketball for providing it. What a great first round win!!!
And there was ice cream. Yum!
@ncons95.bsky.social @rileyirmen.bsky.social
Thank you to UK Women’s Basketball for providing it. What a great first round win!!!
And there was ice cream. Yum!
@ncons95.bsky.social @rileyirmen.bsky.social
March 21, 2025 at 9:17 PM
Macauley Lab needed a win today!
Thank you to UK Women’s Basketball for providing it. What a great first round win!!!
And there was ice cream. Yum!
@ncons95.bsky.social @rileyirmen.bsky.social
Thank you to UK Women’s Basketball for providing it. What a great first round win!!!
And there was ice cream. Yum!
@ncons95.bsky.social @rileyirmen.bsky.social
Super excited to have my first 1st author paper out today! Thanks to all of our collaborators and my mentor @macauleylab.bsky.social !
Our latest in PNAS! 🎉
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate
fluctuations are a biomarker of sleep/wake transitions, where in...
www.pnas.org
February 18, 2025 at 9:56 PM
Super excited to have my first 1st author paper out today! Thanks to all of our collaborators and my mentor @macauleylab.bsky.social !
Reposted by Nick Constantino
Grateful to The Scientist for listening to my story and amplifying our concerns regarding bans on NIH communication and govt funding. www.the-scientist.com/freeze-on-ni...
Freeze on NIH Grant Reviews Leaves Scientists Confused and Frustrated
An unprecedented federal ban on scientific meetings halts research progress, sparking widespread concern across the scientific community.
www.the-scientist.com
January 29, 2025 at 1:43 PM
Grateful to The Scientist for listening to my story and amplifying our concerns regarding bans on NIH communication and govt funding. www.the-scientist.com/freeze-on-ni...