Nathan Beahm
@nathanbeahm.bsky.social
Associate Clinical Professor, University of Alberta. Academic Pharmacist. Infectious Diseases, Antimicrobial Stewardship, Pain Management.
We don't have cefdinir in Canada, which I must say is quite nice.
October 25, 2025 at 7:02 PM
We don't have cefdinir in Canada, which I must say is quite nice.
TID more commonly
January 29, 2025 at 2:45 PM
TID more commonly
Good question. I believe in Hanson's with ENL, the higher daily dose is used for its perceived anti-inflammatory effects. But agreed, the optimal dosing of clofazimine in general is a bit of a mystery. A nice discussion on this from earlier this year here:
doi.org/10.1093/jac/...
doi.org/10.1093/jac/...
Why do we use 100 mg of clofazimine in TB and NTM treatment?
Abstract. Current tuberculosis and non-tuberculous mycobacterial disease guidelines recommend the use of clofazimine in a 100 mg once-daily dose. The ratio
doi.org
December 13, 2024 at 4:50 PM
Good question. I believe in Hanson's with ENL, the higher daily dose is used for its perceived anti-inflammatory effects. But agreed, the optimal dosing of clofazimine in general is a bit of a mystery. A nice discussion on this from earlier this year here:
doi.org/10.1093/jac/...
doi.org/10.1093/jac/...
At this time, I'm not sure what types of patients this could be useful for. Small study, mostly looking at feasibility and tolerance; effectiveness metrics not captured. But interesting, nonetheless!
December 12, 2024 at 8:10 PM
At this time, I'm not sure what types of patients this could be useful for. Small study, mostly looking at feasibility and tolerance; effectiveness metrics not captured. But interesting, nonetheless!
I'm sure the dogma won't die that easily (do they ever?), but certainly a great step in that direction!
November 20, 2024 at 9:11 PM
I'm sure the dogma won't die that easily (do they ever?), but certainly a great step in that direction!
Same here, it seems to be tolerated reasonably well. Similar to 500 mg TID, which has the same amount of clav, of course.
November 19, 2024 at 5:56 AM
Same here, it seems to be tolerated reasonably well. Similar to 500 mg TID, which has the same amount of clav, of course.
Several of us in Edmonton will do amox/clav 875 mg po TID in an attempt to strike a balance between optimizing PK/PD and patient convenience.
November 18, 2024 at 4:46 PM
Several of us in Edmonton will do amox/clav 875 mg po TID in an attempt to strike a balance between optimizing PK/PD and patient convenience.