Yasaman also studied the potential of the JAK inhibitor Itacitinib to treat desmin-related cardiomyopathy. lnkd.in/gigbcdNn

we found that within micro-tissues, iPSC-cardiomyocytes expressed desmin, and mutations that impact protein quality control impact both desmin organization and tissue-level contractility.

PDMS-post based tissues with arbitrary geometry and leveraged this to study the dynamics of nuclear and cell shape changes, and subsequent activation, on the fibroblast-to-myofibroblast transition: lnkd.in/gfME2pC6 . Congrats to Ghiska and team.

This work, published in Biofabrication iopscience.iop.org/article/10.1... that progenitors, which may be easier to use for biomanufacturing, could be used instead of fully differentiated cardiomyocytes.

from iPSC-derived cardiomyocytes or iPSC-derived cardiovascular progenitors. To our surprise, there were no significant differences in physiology, morphology or gene expression when the tissues were aged to a common timepoint.

We are excited for the excellent work Sydney is now doing with @jeffreymillman.bsky.social
and for the new science that comes from Sydney's discovery.

With this "polymer nanopatterning" approach, Sydney found that BOTH peptide density AND the proximity between cell adhesive and growth factor mimicking peptides drive cell fate decisions (here, MSC osteogenesis).

In this work, Sydney studied how integrin-binding adhesive peptides and growth factor mimicking peptides work together to push cell fate decisions. Sydney used orthogonal chemistries to graft these unique peptide types to a common polymer.