Natanael Spisak
@natanaels.bsky.social
I study how mutations come about. Based at @columbiauniversity.bsky.social, previously at @normalesup.bsky.social
Thanks! Indeed, it seems that the NMF model assumptions are correct and there is little interaction between signatures (at least at the level of 96 mutation types). There are exceptions, such as SBS2 and SBS13, which are both due to APOBEC deamination, SBS7* signatures (UV), and then SBS5.
September 5, 2025 at 8:46 PM
Thanks! Indeed, it seems that the NMF model assumptions are correct and there is little interaction between signatures (at least at the level of 96 mutation types). There are exceptions, such as SBS2 and SBS13, which are both due to APOBEC deamination, SBS7* signatures (UV), and then SBS5.