@nataliescholes.bsky.social
Excited to share our work on inhibitors turning degraders now out: doi.org/10.1038/s415...
Inhibitors supercharge kinase turnover through native proteolytic circuits - Nature
Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.
doi.org
November 27, 2025 at 6:13 AM
Excited to share our work on inhibitors turning degraders now out: doi.org/10.1038/s415...
Reposted
🧬 Kinase Inhibitors can do more than block their targets!
A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
November 26, 2025 at 4:05 PM
🧬 Kinase Inhibitors can do more than block their targets!
A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
Reposted
🧬Kinase inhibitors that degrade?
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1
November 26, 2025 at 4:08 PM
🧬Kinase inhibitors that degrade?
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1
Reposted
New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD
November 26, 2025 at 4:14 PM
New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD
Reposted
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
September 2, 2025 at 5:26 PM
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
Reposted
🔬A new computational protocol to explore bioactivity spaces and signatures, out now in @natprot.nature.com!
Researchers at #IRBBarcelona led by @ptck72.bsky.social present a comprehensive pipeline to integrate new bioactivity data into the #ChemicalChecker
Article ➡️ www.nature.com/articles/s41...
Researchers at #IRBBarcelona led by @ptck72.bsky.social present a comprehensive pipeline to integrate new bioactivity data into the #ChemicalChecker
Article ➡️ www.nature.com/articles/s41...
Integration of diverse bioactivity data into the Chemical Checker compound universe - Nature Protocols
The Chemical Checker is a collection of small-molecule bioactivity signatures organized in increasing levels of biological complexity. This protocol describes how to incorporate new data, create novel...
www.nature.com
May 29, 2025 at 8:30 AM
🔬A new computational protocol to explore bioactivity spaces and signatures, out now in @natprot.nature.com!
Researchers at #IRBBarcelona led by @ptck72.bsky.social present a comprehensive pipeline to integrate new bioactivity data into the #ChemicalChecker
Article ➡️ www.nature.com/articles/s41...
Researchers at #IRBBarcelona led by @ptck72.bsky.social present a comprehensive pipeline to integrate new bioactivity data into the #ChemicalChecker
Article ➡️ www.nature.com/articles/s41...
Reposted
📝 🚨 Review alert from the Thomä Lab
@alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action.
tinyurl.com/mpmbuuky
@alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action.
tinyurl.com/mpmbuuky
Primed for degradation: How weak protein interactions enable molecular glue degraders
Molecular glues are small drug-like molecules that induce de novo protein–protein interactions or facilitate pre-existing weak interactions between pr…
tinyurl.com
May 8, 2025 at 9:08 AM
📝 🚨 Review alert from the Thomä Lab
@alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action.
tinyurl.com/mpmbuuky
@alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action.
tinyurl.com/mpmbuuky
Reposted
Hello, we are AITHYRA!
I am very excited to share with you the corporate identity of AITHYRA, the Research Institute for Biomedical AI.
Check out the brand design video (sound on!) to learn more.
**REMINDER**
One week left to apply for Starting PI positions (Life Science and AI/ML). Come join us!
I am very excited to share with you the corporate identity of AITHYRA, the Research Institute for Biomedical AI.
Check out the brand design video (sound on!) to learn more.
**REMINDER**
One week left to apply for Starting PI positions (Life Science and AI/ML). Come join us!
We proudly present to you the #AITHYRA corporate identity, a mixture of logo, motion and sound design. Thanks to our Design Partner Studio Dumbar for a creative and joyful process, and the OeAW and BIS for giving us the confidence and trust to go new ways. More to come www.oeaw.ac.at/aithyra/news...
April 28, 2025 at 8:38 AM
Hello, we are AITHYRA!
I am very excited to share with you the corporate identity of AITHYRA, the Research Institute for Biomedical AI.
Check out the brand design video (sound on!) to learn more.
**REMINDER**
One week left to apply for Starting PI positions (Life Science and AI/ML). Come join us!
I am very excited to share with you the corporate identity of AITHYRA, the Research Institute for Biomedical AI.
Check out the brand design video (sound on!) to learn more.
**REMINDER**
One week left to apply for Starting PI positions (Life Science and AI/ML). Come join us!
Reposted
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
www.training.nih.gov
April 10, 2025 at 1:22 AM
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
Reposted
🚨 Hiring Alert – Senior Scientist (Biology) 🚨
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds
Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds
Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz
AITHYRA
www.oeaw.ac.at
April 7, 2025 at 12:52 PM
🚨 Hiring Alert – Senior Scientist (Biology) 🚨
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds
Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds
Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz